Many diseases are driven by proteins that are aberrantly ubiquitinated and degraded. These
diseases would be therapeutically benefited by targeted protein stabilization (TPS). Here …

Proteolysis-targeting chimeras (PROTACs), heterobifunctional compounds that consist of
protein-targeting ligands linked to an E3 ligase recruiter, have arisen as a powerful therapeutic …

Conspectus One of the biggest bottlenecks in modern drug discovery efforts is in tackling
the undruggable proteome. Currently, over 85% of the proteome is still considered …

Targeted protein degradation (TPD) and proteolysis-targeting chimeras (PROTACs) have
arisen as powerful therapeutic modalities for degrading specific proteins in a proteasome-…

This article examines the production and prominence of literature translated into English,
asking how far we have come toward decentering America’s literary offerings. Through …

Page 701. We noticed an error in the structure of NJH-1-106 in the graphical abstract of our
published Article. The structure in the original publication had a C4 linker, but NJH-1-106 …

In light of their aging societies, both Japan and the US have made national commitments of
varying degrees to address labor shortages in long-term care. Among various policy options …

PGL: I grew up on a farm in northwestern Ohio, so I understood how hard it is to produce
food. Because of the hard work, I wanted to get as far away from the farm as possible. My …

In this study, the predictability of Tropical Storm Erika (2009) is evaluated by analyzing a 60-member
convection-permitting ensemble initialized with perturbations from a real-time …

PURPOSE Many patients with HR+, HER2− early breast cancer (EBC) will not experience
recurrence or have distant recurrence with currently available standard therapies. However, …