During infection, the host sequesters essential nutrients, such as zinc, to combat invading
microbes. Despite the ability of the immune effector protein calprotectin to bind zinc with …

Streptococcus pneumoniae is the primary cause of community-acquired bacterial pneumonia
with rates of penicillin and multidrug-resistance exceeding 80% and 40%, respectively. …

Human zinc deficiency increases susceptibility to bacterial infection. Although zinc
supplementation therapies can reduce the impact of disease, the molecular basis for protection …

The World Health Organization reports that antibiotic-resistant pathogens represent an imminent
global health disaster for the 21st century. Gram-positive superbugs threaten to breach …

During infection, the host utilizes a diverse array of processes to combat invaders, including
the restriction of availability of essential nutrients such as manganese. Similarly to many …

Bacterial fatty acids are critical components of the cellular membrane. A shift in environmental
conditions or in the bacterium’s lifestyle may result in the requirement for a distinct pool of …

Zinc is an essential trace element that serves as a catalytic cofactor in metalloenzymes and
a structural element in proteins involved in general metabolism and cellular defenses of …

Acinetobacter baumannii is one of the world’s most problematic nosocomial pathogens. The
combination of its intrinsic resistance and ability to acquire resistance markers allow this …

Streptococcus pneumoniae is capable of randomly switching their genomic DNA methylation
pattern between six distinct bacterial subpopulations (AF) via recombination of a type 1 …

Maintaining optimal fluidity is essential to ensure adequate membrane structure and function
under different environmental conditions. We apply integrated molecular approaches to …