Type 2 diabetes mellitus and its precursor, insulin resistance, are metabolic disease states
characterized by impaired regulation in the delivery, transport, and/or storage of energy …

The purpose of this study was to determine the effects of glucocorticoid-induced metabolic
dysfunction in the presence of diet-induced obesity. C57BL/6J adult male lean and diet-…

Secretory phospholipase A 2 group IIA (PLA2G2A) is a member of a family of secretory
phospholipases that have been implicated in inflammation, atherogenesis, and antibacterial …

Almost all effective treatments for non-alcoholic fatty liver disease (NAFLD) involve reduction
of adiposity, which suggests the metabolic axis between liver and adipose tissue is …

We have used a novel model of genetically imparted endurance exercise capacity and
metabolic health to study the genetic and environmental contributions to skeletal muscle glucose …

Inactivity-related diseases are becoming a huge burden on Western society. While there is
a major environmental contribution to metabolic health, the intrinsic properties that …

Impaired visceral white adipose tissue (WAT) metabolism has been implicated in the pathogenesis
of several lifestyle-related disease states, with diminished expression of several WAT …

Duchenne muscular dystrophy (DMD) is a neuromuscular disease that predominantly
affects boys as a result of mutation(s) in the dystrophin gene. DMD is characterized by …

Glucocorticoids have major effects on adipose tissue metabolism. To study tissue mRNA
expression changes induced by chronic elevated endogenous glucocorticoids, we performed …

Background The increased prevalence of obesity and its co-morbidities and their strong
association with inactivity have produced an ‘exercise-deficient phenotype’ in which individuals …