INTRODUCTION The rhesus macaque (Macaca mulatta) is one of the most widely used
nonhuman primate (NHP) models for studying human biology and disease. As a representative …

Epigenetic mechanisms may moderate genetic and environmental risk (G×E) for mood
disorders. We used an experimental rhesus macaque model of early life stress to test whether …

Background: Physical or psychological adversity in childhood is associated with a higher risk
for depression in adulthood, and with persistent serotonergic abnormalities in humans and …

Epigenetic marks (eg, DNA 5-methylcytosine [5mC] content or CpG methylation) within
specific gene regulatory regions have been demonstrated to play diverse roles in stress …

Objectives Adverse childhood experiences are associated with poor mental health
outcomes, including vulnerability to mood disorders and/or antisocial behavior. A functional …

BACKGROUND: Studies have been inconsistent in demonstrating that early adversity and
specific genotype can be joint risk factors for poor behavioral outcomes. Using a rhesus …

A subset of serotonin (5-HT) pathway polymorphisms has been shown to confer risk for
psychological dysfunction, particularly in individuals who experience early adversity. …

Early social stress has potent lifelong health effects. We examined the association of early
stress in the attachment relationship (low maternal sensitivity, low MS), lower maternal social …

Background Early experiences influence the developing organism, with lifelong and potentially
adaptive consequences. It has recently become clear that the effects of early experiences …

An anxious or inhibited temperament (IT) early in life is a major risk factor for the later
development of stress-related psychopathology. Starting in infancy, nonhuman primates, like …