Reconstructing the 3D genome organization of Neanderthals reveals that chromatin folding shaped phenotypic and sequence divergence
Abstract Changes in gene regulation were a major driver of the divergence of archaic
hominins (AHs)—Neanderthals and Denisovans—and modern humans (MHs). The three-…
hominins (AHs)—Neanderthals and Denisovans—and modern humans (MHs). The three-…
Evidence for rapid phenotypic and behavioural shifts in a recently established cavefish population
SE McGaugh, S Weaver, EN Gilbertson… - Biological Journal of …, 2020 - academic.oup.com
Cave colonization offers a natural laboratory to study an extreme environmental shift, and
diverse cave species from around the world often have converged on robust morphological, …
diverse cave species from around the world often have converged on robust morphological, …
[HTML][HTML] Machine learning reveals the diversity of human 3D chromatin contact patterns
Understanding variation in chromatin contact patterns across human populations is critical
for interpreting non-coding variants and their ultimate effects on gene expression and …
for interpreting non-coding variants and their ultimate effects on gene expression and …
[HTML][HTML] Sequence-based machine learning reveals 3D genome differences between bonobos and chimpanzees
Phenotypic divergence between closely related species, including bonobos and chimpanzees
(genus Pan), is largely driven by variation in gene regulation. The 3D structure of the …
(genus Pan), is largely driven by variation in gene regulation. The 3D structure of the …
Evidence for rapid phenotypic and behavioral change in a recently established cavefish population
SE McGaugh, S Weaver, EN Gilbertson, B Garrett… - BioRxiv, 2019 - biorxiv.org
Substantial morphological and behavioral shifts often accompany rapid environmental change,
yet, little is known about the early stages of cave colonization. Relative to surface streams…
yet, little is known about the early stages of cave colonization. Relative to surface streams…
Myc and loss of p53 cooperate to drive formation of choroid plexus carcinoma
…, CG Eberhart, RC Sears, MF Roussel, RJ Gilbertson… - Cancer research, 2019 - AACR
This study describes new mouse models of choroid plexus carcinoma and uses them to
investigate the biology and therapeutic responsiveness of this highly malignant pediatric brain …
investigate the biology and therapeutic responsiveness of this highly malignant pediatric brain …
First Report of Cucurbit yellow stunting disorder virus in California and Arizona, in Association with Cucurbit leaf crumple virus and Squash leaf curl virus
YW Kuo, MR Rojas, RL Gilbertson… - Plant …, 2007 - Am Phytopath Society
In August and September of 2006, melon plants ( Cucumis melo L.) near Niland in
California's Imperial Valley and near Yuma, AZ began exhibiting interveinal chlorosis and leaf …
California's Imperial Valley and near Yuma, AZ began exhibiting interveinal chlorosis and leaf …
[HTML][HTML] Novel mutations target distinct subgroups of medulloblastoma
Medulloblastoma is a malignant childhood brain tumour comprising four discrete subgroups.
Here, to identify mutations that drive medulloblastoma, we sequenced the entire genomes …
Here, to identify mutations that drive medulloblastoma, we sequenced the entire genomes …
C11orf95–RELA fusions drive oncogenic NF-κB signalling in ependymoma
Members of the nuclear factor-κB (NF-κB) family of transcriptional regulators are central
mediators of the cellular inflammatory response. Although constitutive NF-κB signalling is …
mediators of the cellular inflammatory response. Although constitutive NF-κB signalling is …
The origins of medulloblastoma subtypes
RJ Gilbertson, DW Ellison - Annu. Rev. Pathol. Mech. Dis., 2008 - annualreviews.org
Childhood tumors containing cells that are morphologically and functionally similar to normal
progenitor cells provide fertile ground for investigating the links between development and …
progenitor cells provide fertile ground for investigating the links between development and …