Nonclinical rodent and nonrodent toxicity models used to support clinical trials of candidate
drugs may produce discordant results or fail to predict complications in humans, contributing …

Purpose: The receptor tyrosine kinase c-Met plays an important role in tumorigenesis and is
a novel target for anticancer treatment. This phase I, first-in-human trial, explored safety, …

The history of immunohistochemistry started in 1941 when Coons identified pneumococci
using a direct fluorescent method. Then followed the indirect method, the addition of …

The kidney is one of the main targets of drug toxicity, and early detection of renal damage is
critical in preclinical drug development. A model of cisplatin-induced nephrotoxicity in male …

Pathology peer review verifies and improves the accuracy and quality of pathology
diagnoses and interpretations. Pathology peer review is recommended when important risk …

Nonclinical rodent and non-rodent toxicity models used to support clinical trials of candidate
drugs may produce discordant results or fail to predict complications in humans contributing …

To address the challenges posed by large-scale development, validation, and adoption of
artificial intelligence (AI) in pathology, we have constituted a consortium of academics, small …

With advancements in whole slide imaging technology and improved understanding of the
features of pathologist workstations required for digital slide evaluation, many institutions are …

The main objective of this 28-day oral gavage toxicity study in the rat was to investigate which
of the current and/or additional parameters of the OECD Test Guideline 407 would reliably …

The International Federation of Societies of Toxicologic Pathologists (IFSTP) proposes a
common global framework for training future toxicologic pathologists who will support regulatory…