We summarize recent progress in using iPSCs for modeling the progress and treatment of
neurodegenerative diseases and provide evidence for future perspectives in this field.

Multiplex genome editing is the simultaneous introduction of multiple distinct modifications
to a given genome. Though in its infancy, maturation of this field will facilitate powerful new …

Since the elucidation of its structure, DNA has been at the forefront of biological research. In
the past half century, an explosion of DNA‐based technology development has occurred …

Reprogramming to pluripotency after overexpression of OCT4, SOX2, KLF4, and MYC is
accompanied by global genomic and epigenomic changes. Histone modification and DNA …

Rett syndrome (RTT) is one of the most prevalent female neurodevelopmental disorders that
cause severe mental retardation. Mutations in methyl CpG binding protein 2 (MeCP2) are …

Embryonic stem cells (ESCs) maintain pluripotency through unique epigenetic states. When
ESCs commit to a specific lineage, epigenetic changes in histones and DNA accompany the …

The Ten-Eleven-Translocation 2 (TET2) gene, which oxidates 5-methylcytosine in DNA to 5-hydroxylmethylcytosine
(5hmC), is a key tumor suppressor frequently mutated in …

Rett syndrome (RTT), mainly caused by mutations in methyl-CpG binding protein 2 (MeCP2),
is one of the most prevalent intellectual disorders without effective therapies. Here, we …

Whole-genome recoding has been shown to enable nonstandard amino acids, biocontainment
and viral resistance in bacteria. Here we take the first steps to extend this to human cells …

Understanding the evolutionary stability and possible context dependence of biological
containment techniques is critical as engineered microbes are increasingly under consideration …