During eukaryotic cell division, chromosomes must be precisely partitioned to daughter cells.
This relies on a mechanism to move chromosomes in defined directions within the parental …

Set2 (KMT3)-dependent methylation (me) of histone H3 at lysine 36 (H3K36) promotes
deacetylation of transcribed chromatin and represses cryptic promoters within genes. Although …

Budding yeast Mms22 is required for homologous recombination (HR)-mediated repair of
stalled or broken DNA replication forks. Here we identify a human Mms22-like protein (…

Production of healthy gametes requires a reductional meiosis I division in which replicated
sister chromatids comigrate, rather than separate as in mitosis or meiosis II. Fusion of sister …

Yeast cells lacking MMS22 or MMS1 are hypersensitive to agents that perturb replisome
progression but the cellular functions of these genes are unknown. In this study we investigate …

Kinetochores direct chromosome segregation in mitosis and meiosis. Faithful gamete formation
through meiosis requires that kinetochores take on new functions that impact homolog …

In the Neisseria spp., natural competence for transformation and homologous recombination
generate antigenic variants through creation of mosaic genes (such as opas) and through …

The monopolin complex is a multifunctional molecular crosslinker, which in S. pombe binds
and organises mitotic kinetochores to prevent aberrant kinetochore-microtubule interactions. …

University of Dundee DOCTOR OF PHILOSOPHY Identification of MMS22 as a regulator of
DNA repair Duro, Eris … Eris Duro I certify that Eris Duro has spent the equivalent of at least …

Sister chromatids move toward opposite poles of the spindle during mitosis. Strikingly
however, they must instead co-migrate toward the same pole during phase I of meiosis, the …