Hepatocyte growth factor/scatter factor and its receptor, the tyrosine kinase Met, arose late in
evolution and are unique to vertebrates. In spite of this, Met uses molecules such as Gab1 …

POLYPEPTIDE growth factors are important effectors of cell growth and differentiation in vitro
and are thought to be critical for processes such as specification of cell fate, tissue growth …

Various factors are known to regulate cell growth and differentiation, but less is known of
agents which affect movement and positioning, particularly in epithelial-mesenchymal …

Uncontrolled cell survival, growth, angiogenesis and metastasis are essential hallmarks of
cancer. Genetic and biochemical data have demonstrated that the growth and motility factor …

The V H gene segments produce the part of the V H domains of antibodies that contains the
first two hypervariable regions. The sequences of 83 human V H segments with open …

A number of developmental processes that involve cell migration, growth or morphogenesis
depend on extracellular signals. A molecule that provides such signals, known as …

We describe a new method for random mutagenesis of DNA based on the use of a mixture
of triphosphates of nucleoside analogues. The method relies on DNA amplificationin …

Scatter factor is a fibroblast-derived protein that causes separation of contiguous epithelial
cells and increased local mobility of unanchored cells. Highly purified scatter factor has been …

CD44 has been implicated in tumor progression and metastasis, but the mechanism(s) involved
is as yet poorly understood. Recent studies have shown that CD44 isoforms containing …

For a number of years a major limitation in genetic analysis of protein function has been the
inability to introduce multiple substitutions at distant sites that would enable the selection of …