Accurately modeling oxygen transport and consumption is crucial to predict metabolic
dynamics in cell cultures and optimize the design of tissue and organ models. We present a …

Variations and fluctuations are characteristic features of biological systems and are also
manifested in cell cultures. Here, we describe a computational pipeline for identifying the range …

Dose assessment is essential for understanding the mechanisms triggering nanomaterial
toxicity in vitro and for meaningful translations to in vivo. We propose a novel computational …

Oxygen utilization by cells has a crucial role in the design of advanced in vitro models. The
aim of this study is to develop an experimental and computational pipeline for identifying …

Accurate dosing of nanoparticles is crucial for risk assessment and for their safe use in medical
and other applications. Although it is well-known that nanoparticles sediment, diffuse and …

In vitro platforms such as bioreactors and microfluidic devices are commonly designed to
engineer tissue models as well as to replicate the crosstalk between cells and microorganisms …

The final goal a course of Medical Device Design is to convey the importance of multidisciplinary
approach in Biomedical Engineering (BME), where scientific and technical knowledge …

L’obiettivo del presente lavoro di tesi è consistito nell’ottimizzazione e nella fabbricazione di
una camera di coltura che consenta di coltivare in vitro il microbiota intestinale umano e di …

A multidisciplinary approach is necessary to design medical devices. Scientific and technical
knowledge has to address the clinical needs of patients and healthcare providers, and …

We combined microfabricated devices with multiparameter identification algorithms to probe
the variability in size-dependent oxygen consumption parameters of single human hepatic …