In this work, we propose a deep learning approach to improve docking-based virtual
screening. The deep neural network that is introduced, DeepVS, uses the output of a docking …

The aim of this report is to investigate at microscopic level the elastic properties of a
tropocollagen-like molecule submitted to linear traction along its longitudinal axis. For this purpose, …

Conflicting findings about the association between leprosy and TLR1 variants N248S and
I602S have been reported. Here, we performed case-control and family based studies, …

Malaria remains one of the most serious global infectious diseases. An important target for
antimalarial chemotherapy is the enzyme dihydroorotate dehydrogenase from Plasmodium …

Southeastern Brazil has been suffering a rapid expansion of a severe sylvatic yellow fever
virus (YFV) outbreak since late 2016, which has reached one of the most populated zones in …

Objetivo Descrever o estágio do envelhecimento populacional no município do Rio de
Janeiro. Métodos Estudo ecológico tendo como unidades de observação os 160 bairros que …

Brain-derived neurotrophic factor (BDNF) plays an important role in neurogenesis and
synapse formation. The V66M is the most prevalent BDNF mutation in humans and impairs the …

Leishmania ( Leishmania ) amazonensis is a protozoan that causes infections with a broad
spectrum of clinical manifestations. The currently available chemotherapeutic treatments …

Reverse transcriptase (RT) is a multifunctional enzyme in the human immunodeficiency
virus (HIV)-1 life cycle and represents a primary target for drug discovery efforts against HIV-1 …

Currently, adenosine 5′-triphosphate (ATP) is recognized as the extracellular messenger
that acts through P2 receptors. P2 receptors are divided into two subtypes: P2Y metabotropic …