Functionally diverse T cell populations interact to maintain homeostasis of the immune
system. We found that human and mouse antigen-activated T cells with high expression of the …

Differentiation of naïve CD4 + T cells into effector (Th1, Th2, and Th17) and induced
regulatory (iTreg) T cells requires lineage-specifying transcription factors and epigenetic …

CD52, a glycophosphatidylinositol (GPI)-anchored glycoprotein, is released in a soluble
form following T cell activation and binds to the Siglec (sialic acid-binding Ig-like lectin)-10 …

Remodelling of chromatin architecture is known to regulate gene expression and has been
well characterized in cell lineage development but less so in response to cell perturbation. …

RIPK1 is an essential downstream component of many pattern recognition and death
receptors. RIPK1 can promote the activation of caspase-8 induced apoptosis and RIPK3-MLKL-…

The complex cytopathology of mitochondrial diseases is usually attributed to insufficient ATP.
AMP-activated protein kinase (AMPK) is a highly sensitive cellular energy sensor that is …

To optimise fecal sampling for reproducible analysis of the gut microbiome, we compared
different methods of sample collection and sequencing of 16S rRNA genes at two centers. …

Soluble CD52 is a small glycoprotein that suppresses T-cell activation, but its effect on innate
immune cell function is unknown. Here we demonstrate that soluble CD52 inhibits Toll-like …

Following activation by antigen, T cells enter the cell cycle in stages that can be defined with
flow cytometric markers. We show that these markers include the increase of forward light …

Purpose: To evaluate the effect of intravitreal ranibizumab injections on aqueous concentrations
of angiogenic or inflammatory cytokines in patients with diabetic macular edema (DME). …