Reproducible science requires transparent reporting. The ARRIVE guidelines (Animal
Research: Reporting of In Vivo Experiments) were originally developed in 2010 to improve the …

Improving the reproducibility of biomedical research is a major challenge. Transparent and
accurate reporting is vital to this process; it allows readers to assess the reliability of the …

Epithelial invagination is a fundamental module of morphogenesis that iteratively occurs to
generate the architecture of many parts of a developing organism. By changing the physical …

Xenopus is an essential vertebrate model system for biomedical research that has contributed
to important discoveries in many disciplines, including cell biology, molecular biology, …

In animal experiments, blinding (also known as masking) is a methodological strategy to
reduce the risk that scientists, animal care staff, or other staff involved in the research may …

Background Epimorphic regeneration is the process by which complete regeneration of a
complex structure such as a limb occurs through production of a proliferating blastema. This …

Mutations in rfx6 were recently associated with Mitchell–Riley syndrome, which involves
neonatal diabetes, and other digestive system defects. To better define the function of Rfx6 in …

Understanding how the pancreas develops is vital to finding new treatments for a range of
pancreatic diseases, including diabetes and pancreatic cancer. Xenopus is a relatively new …

Xenopus laevis embryos are an established model for studying kidney development. The
nephron structure and genetic pathways that regulate nephrogenesis are conserved between …

As the Cne PRP8 intein is active and exists in an essential gene of an important fungal
pathogen, inhibitors of splicing and assays for intein activity are of interest. The self-splicing …