Opposing activities of two novel members of the IL-1 ligand family regulate skin inflammation

H Blumberg, H Dinh, ES Trueblood… - The Journal of …, 2007 - rupress.org
The interleukin (IL)-1 family members IL-1α, -1β, and -18 are potent inflammatory cytokines
whose activities are dependent on heterodimeric receptors of the IL-1R superfamily, and …

IL-1RL2 and its ligands contribute to the cytokine network in psoriasis

H Blumberg, H Dinh, C Dean, ES Trueblood… - The Journal of …, 2010 - journals.aai.org
Psoriasis is a common immune-mediated disease in European populations; it is characterized
by inflammation and altered epidermal differentiation leading to redness and scaling. T …

Expression of Trop2 cell surface glycoprotein in normal and tumor tissues: potential implications as a cancer therapeutic target

LP Stepan, ES Trueblood, K Hale… - … of Histochemistry & …, 2011 - journals.sagepub.com
Trop2 is a cell-surface glycoprotein reported to be overexpressed in various types of
adenocarcinomas with minimal expression in normal tissues. Recent findings that Trop2 expression …

Mechanisms of oncostatin M-induced pulmonary inflammation and fibrosis

A Mozaffarian, AW Brewer, ES Trueblood… - The Journal of …, 2008 - journals.aai.org
Oncostatin M (OSM), an IL-6 family cytokine, has been implicated in a number of biological
processes including the induction of inflammation and the modulation of extracellular matrix. …

[HTML][HTML] Drug repurposing: the anthelmintics niclosamide and nitazoxanide are potent TMEM16A antagonists that fully bronchodilate airways

…, R Elliott, JJ Chen, L Liu, A Leith, E Trueblood… - Frontiers in …, 2019 - frontiersin.org
There is an unmet need in severe asthma where approximately 40% of patients exhibit poor
β-agonist responsiveness, suffer daily symptoms and show frequent exacerbations. …

AMG 595, an anti-EGFRvIII antibody–drug conjugate, induces potent antitumor activity against EGFRvIII-expressing glioblastoma

…, S Siu, WS Chang, H Liu, IN Foltz, ES Trueblood… - Molecular cancer …, 2015 - AACR
Epidermal growth factor receptor variant III (EGFRvIII) is a cancer-specific deletion mutant
observed in approximately 25% to 50% of glioblastoma multiforme (GBM) patients. An …

Characterization of the inflammatory response to a highly selective PDE4 inhibitor in the rat and the identification of biomarkers that correlate with toxicity

…, NB Pefaur, WD Welch, E Trueblood… - Toxicologic …, 2006 - journals.sagepub.com
The primary toxicity associated with repeated oral administration of the PDE4 inhibitor
IC542 to the rat is an inflammatory response leading to tissue damage primarily in the …

Retinal toxicity induced by a novel β-secretase inhibitor in the Sprague-Dawley rat

…, D Hickman, RT Dunn, E Trueblood… - Toxicologic …, 2015 - journals.sagepub.com
β-Secretase 1 (BACE1) represents an attractive target for the treatment of Alzheimer’s
disease. In the course of development of a novel small molecule BACE1 inhibitor (AMG-8718), …

B-lymphocyte proliferation during bovine leukemia virusinduced persistent lymphocytosis is enhanced by T-lymphocyte-derived interleukin-2

ES Trueblood, WC Brown, GH Palmer… - Journal of …, 1998 - Am Soc Microbiol
Bovine leukemia virus (BLV)-induced persistent lymphocytosis is characterized by a
polyclonal expansion of CD5 + B lymphocytes. To examine the role of the cytokine …

[HTML][HTML] SGN-B7H4V, an investigational vedotin ADC directed to the immune checkpoint ligand B7-H4, shows promising activity in preclinical models

…, K Gahnberg, PM Treuting, ES Trueblood… - … for ImmunoTherapy of …, 2023 - ncbi.nlm.nih.gov
Background SGN-B7H4V is a novel investigational vedotin antibody–drug conjugate (ADC)
comprising a B7-H4-directed human monoclonal antibody conjugated to the cytotoxic …