The RNA-guided nuclease Cas9 can be reengineered as a programmable transcription
factor. However, modest levels of gene activation have limited potential applications. We …

INTRODUCTION Cells and tissues are made up of diverse molecular building blocks,
organized with nanoscale precision over extended length scales. Newly developed techniques …

… Eswar PR Iyer … Eswar PR Iyer … Eswar PR Iyer is a postdoctoral fellow at Harvard Medical
School and the Wyss Institute for Biologically Inspired Engineering at Harvard University. …

We present barcoded oligonucleotides ligated on RNA amplified for multiplexed and
parallel insitu analyses (BOLORAMIS), a reverse transcription-free method for spatially-resolved, …

Activated fibroblasts are the central effector cells of the progressive fibrotic process in idiopathic
pulmonary fibrosis (IPF). Characterizing the genomic phenotype of isolated fibroblasts is …

We present Barcoded Oligonucleotides Ligated On RNA Amplified for Multiplexed and
parallel In-Situ analysis (BOLORAMIS), a reverse-transcription (RT)-free method for spatially-…

The basic mechanisms underlying noxious cold perception are not well understood. We
developed Drosophila assays for noxious cold responses. Larvae respond to near-freezing …

Led by NOAA’s Storm Prediction Center and National Severe Storms Laboratory, annual
spring forecasting experiments (SFEs) in the Hazardous Weather Testbed test and evaluate …

Previous studies examining convection-allowing models (CAMs), as well as NOAA/Hazardous
Weather Testbed Spring Forecasting Experiments (SFEs) have typically emphasized “day …

Peptides are ideal biologicals for targeted drug delivery and have also been increasingly
employed as theranostic tools in treating various diseases, including cancer, with minimal or …