User profiles for Ethan D. Buhr

Ethan Buhr

University of Washington
Verified email at uw.edu
Cited by 10399

PERIOD2:: LUCIFERASE real-time reporting of circadian dynamics reveals persistent circadian oscillations in mouse peripheral tissues

…, K Shimomura, CH Ko, ED Buhr… - Proceedings of the …, 2004 - National Acad Sciences
Mammalian circadian rhythms are regulated by the suprachiasmatic nucleus (SCN), and
current dogma holds that the SCN is required for the expression of circadian rhythms in …

Disruption of the clock components CLOCK and BMAL1 leads to hypoinsulinaemia and diabetes

B Marcheva, KM Ramsey, ED Buhr, Y Kobayashi, H Su… - Nature, 2010 - nature.com
The molecular clock maintains energy constancy by producing circadian oscillations of rate-limiting
enzymes involved in tissue metabolism across the day and night 1 , 2 , 3 . During …

Circadian Clock Feedback Cycle Through NAMPT-Mediated NAD+ Biosynthesis

…, B Marcheva, HK Hong, JL Chong, ED Buhr… - Science, 2009 - science.org
The circadian clock is encoded by a transcription-translation feedback loop that synchronizes
behavior and metabolism with the light-dark cycle. Here we report that both the rate-…

Temperature as a universal resetting cue for mammalian circadian oscillators

ED Buhr, SH Yoo, JS Takahashi - science, 2010 - science.org
Environmental temperature cycles are a universal entraining cue for all circadian systems at
the organismal level with the exception of homeothermic vertebrates. We report here that …

Molecular components of the Mammalian circadian clock

ED Buhr, JS Takahashi - Circadian clocks, 2013 - Springer
Mammals synchronize their circadian activity primarily to the cycles of light and darkness in
the environment. This is achieved by ocular photoreception relaying signals to the …

[HTML][HTML] Intercellular coupling confers robustness against mutations in the SCN circadian clock network

…, CH Ko, HG Tran, EE Zhang, AA Priest, ED Buhr… - Cell, 2007 - cell.com
Molecular mechanisms of the mammalian circadian clock have been studied primarily by
genetic perturbation and behavioral analysis. Here, we used bioluminescence imaging to …

A noncanonical E-box enhancer drives mouse Period2 circadian oscillations in vivo

SH Yoo, CH Ko, PL Lowrey, ED Buhr… - Proceedings of the …, 2005 - National Acad Sciences
The mouse Period2 (mPer2) locus is an essential negative-feedback element of the
mammalian circadian-clock mechanism. Recent work has shown that mPer2 circadian gene …

The mouse Clock mutation reduces circadian pacemaker amplitude and enhances efficacy of resetting stimuli and phase–response curve amplitude

…, CH Ko, AM Chang, ED Buhr… - Proceedings of the …, 2006 - National Acad Sciences
The mouse Clock gene encodes a basic helix–loop–helix-PAS transcription factor, CLOCK,
that acts in concert with BMAL1 to form the positive elements of the circadian clock …

[HTML][HTML] Emergence of noise-induced oscillations in the central circadian pacemaker

CH Ko, YR Yamada, DK Welsh, ED Buhr, AC Liu… - PLoS …, 2010 - journals.plos.org
Bmal1 is an essential transcriptional activator within the mammalian circadian clock. We
report here that the suprachiasmatic nucleus (SCN) of Bmal1-null mutant mice, unexpectedly, …

Violet-light suppression of thermogenesis by opsin 5 hypothalamic neurons

…, NT Petts, M Batie, R Mukherjee, D Tiwari, ED Buhr… - Nature, 2020 - nature.com
The opsin family of G-protein-coupled receptors are used as light detectors in animals. Opsin
5 (also known as neuropsin or OPN5) is a highly conserved opsin that is sensitive to visible …