User profiles for Ethan D. Buhr
Ethan BuhrUniversity of Washington Verified email at uw.edu Cited by 10399 |
PERIOD2:: LUCIFERASE real-time reporting of circadian dynamics reveals persistent circadian oscillations in mouse peripheral tissues
Mammalian circadian rhythms are regulated by the suprachiasmatic nucleus (SCN), and
current dogma holds that the SCN is required for the expression of circadian rhythms in …
current dogma holds that the SCN is required for the expression of circadian rhythms in …
Disruption of the clock components CLOCK and BMAL1 leads to hypoinsulinaemia and diabetes
The molecular clock maintains energy constancy by producing circadian oscillations of rate-limiting
enzymes involved in tissue metabolism across the day and night 1 , 2 , 3 . During …
enzymes involved in tissue metabolism across the day and night 1 , 2 , 3 . During …
Circadian Clock Feedback Cycle Through NAMPT-Mediated NAD+ Biosynthesis
…, B Marcheva, HK Hong, JL Chong, ED Buhr… - Science, 2009 - science.org
The circadian clock is encoded by a transcription-translation feedback loop that synchronizes
behavior and metabolism with the light-dark cycle. Here we report that both the rate-…
behavior and metabolism with the light-dark cycle. Here we report that both the rate-…
Temperature as a universal resetting cue for mammalian circadian oscillators
Environmental temperature cycles are a universal entraining cue for all circadian systems at
the organismal level with the exception of homeothermic vertebrates. We report here that …
the organismal level with the exception of homeothermic vertebrates. We report here that …
Molecular components of the Mammalian circadian clock
ED Buhr, JS Takahashi - Circadian clocks, 2013 - Springer
Mammals synchronize their circadian activity primarily to the cycles of light and darkness in
the environment. This is achieved by ocular photoreception relaying signals to the …
the environment. This is achieved by ocular photoreception relaying signals to the …
[HTML][HTML] Intercellular coupling confers robustness against mutations in the SCN circadian clock network
Molecular mechanisms of the mammalian circadian clock have been studied primarily by
genetic perturbation and behavioral analysis. Here, we used bioluminescence imaging to …
genetic perturbation and behavioral analysis. Here, we used bioluminescence imaging to …
A noncanonical E-box enhancer drives mouse Period2 circadian oscillations in vivo
The mouse Period2 (mPer2) locus is an essential negative-feedback element of the
mammalian circadian-clock mechanism. Recent work has shown that mPer2 circadian gene …
mammalian circadian-clock mechanism. Recent work has shown that mPer2 circadian gene …
The mouse Clock mutation reduces circadian pacemaker amplitude and enhances efficacy of resetting stimuli and phase–response curve amplitude
The mouse Clock gene encodes a basic helix–loop–helix-PAS transcription factor, CLOCK,
that acts in concert with BMAL1 to form the positive elements of the circadian clock …
that acts in concert with BMAL1 to form the positive elements of the circadian clock …
[HTML][HTML] Emergence of noise-induced oscillations in the central circadian pacemaker
Bmal1 is an essential transcriptional activator within the mammalian circadian clock. We
report here that the suprachiasmatic nucleus (SCN) of Bmal1-null mutant mice, unexpectedly, …
report here that the suprachiasmatic nucleus (SCN) of Bmal1-null mutant mice, unexpectedly, …
Violet-light suppression of thermogenesis by opsin 5 hypothalamic neurons
The opsin family of G-protein-coupled receptors are used as light detectors in animals. Opsin
5 (also known as neuropsin or OPN5) is a highly conserved opsin that is sensitive to visible …
5 (also known as neuropsin or OPN5) is a highly conserved opsin that is sensitive to visible …