Deep sequencing of the gut microbiomes of 1135 participants from a Dutch population-based
cohort shows relations between the microbiome and 126 exogenous and intrinsic host …

Approximately 1.5 billion people worldwide are overweight or affected by obesity, and are at
risk of developing type 2 diabetes, cardiovascular disease and related metabolic and …

Background and aims Proton pump inhibitors (PPIs) are among the top 10 most widely used
drugs in the world. PPI use has been associated with an increased risk of enteric infections, …

Fecal microbiome variation in the average, healthy population has remained under-investigated.
Here, we analyzed two independent, extensively phenotyped cohorts: the Belgian …

The gut microbiome is affected by multiple factors, including genetics. In this study, we
assessed the influence of host genetics on microbial species, pathways and gene ontology …

The relationship between gut microbial metabolism and mental health is one of the most
intriguing and controversial topics in microbiome research. Bidirectional microbiota–gut–brain …

Rationale: Evidence suggests that the gut microbiome is involved in the development of
cardiovascular disease, with the host–microbe interaction regulating immune and metabolic …

Changes in the gut microbiota have been associated with two of the most common gastrointestinal
diseases, inflammatory bowel disease (IBD) and irritable bowel syndrome (IBS). Here…

Most disease-associated genetic variants are noncoding, making it challenging to design
experiments to understand their functional consequences 1 , 2 . Identification of expression …

Genetic risk factors often localize to noncoding regions of the genome with unknown effects
on disease etiology 1 , 2 . Expression quantitative trait loci (eQTLs) help to explain the …