Carnosine is an endogenous dipeptide whose oral administration has been found to prevent
several oxidative based diseases including lung disease, type 2 diabetes and its micro and …

Sugar- and lipid-derived aldehydes are reactive carbonyl species (RCS) frequently used as
surrogate markers of oxidative stress in obesity. A pathogenic role for RCS in metabolic …

We present the first in vivo comparative evaluation of chemically defined antibody–drug
conjugates (ADCs), small molecule–drug conjugates (SMDCs), and peptide–drug conjugates (…

Cytokine-based therapeutics have been shown to mediate objective responses in certain
tumor entities but suffer from insufficient selectivity, causing limiting toxicity which prevents …

The study combines HPLC-based with MS-based competitive analyses to evaluate the
quenching activity of a set of carnosine derivatives towards methylglyoxal (MGO) and …

Carnosine (beta-alanyl-l-histidine) and its methylated analogue anserine are present in
relevant concentrations in the omnivore human diet. Several studies reported promising …

Purpose: Small molecule drug conjugates (SMDC) are modular anticancer prodrugs that
include a tumor-targeting small organic ligand, a cleavable linker, and a potent cytotoxic agent. …

Background Recent studies suggest that acute-combined carnosine and anserine supplementation
has the potential to improve the performance of certain cycling protocols. Yet, data …

The human inducible phospho-fructokinase bisphosphatase isoform 3, PFKFB3, is a crucial
regulatory node in the cellular metabolism. The enzyme is an important modulator regulating …

Carnosine (β-alanyl-L-histidine) is a natural peptide that have been described as a potential
pharmacological agent owing to some positive outcomes from several pharmacological …