Personalized medicine is expected to benefit from combining genomic information with regular
monitoring of physiological states by multiple high-throughput methods. Here, we present …

There is great potential for genome sequencing to enhance patient care through improved
diagnostic sensitivity and more precise therapeutic targeting. To maximize this potential, …

Background The cost of genomic information has fallen steeply, but the clinical translation of
genetic risk estimates remains unclear. We aimed to undertake an integrated analysis of a …

Characterized by ventricular dilatation, systolic dysfunction, and progressive heart failure,
dilated cardiomyopathy (DCM) is the most common form of cardiomyopathy in patients. DCM is …

Familial hypertrophic cardiomyopathy (HCM) is a prevalent hereditary cardiac disorder linked
to arrhythmia and sudden cardiac death. While the causes of HCM have been identified as …

The ability to measure physical activity through wrist-worn devices provides an opportunity for
cardiovascular medicine. However, the accuracy of commercial devices is largely unknown…

Accurate assessment of cardiac function is crucial for the diagnosis of cardiovascular
disease 1 , screening for cardiotoxicity 2 and decisions regarding the clinical management of …

Live-cell imaging has opened an exciting window into the role cellular heterogeneity plays
in dynamic, living systems. A major critical challenge for this class of experiments is the …

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Objective: The endogenous peptide apelin is differentially regulated in cardiovascular disease
but the nature of its role in cardiac function remains unclear. Methods: We investigated …