Background Diet-induced obesity (DIO) is a significant health concern which has been
linked to structural and functional changes in the gut microbiota. Exercise (Ex) is effective in …

T cell infiltration of solid tumors is associated with favorable patient outcomes, yet the mechanisms
underlying variable immune responses between individuals are not well understood. …

Circadian clocks and metabolism are inextricably intertwined, where central and hepatic
circadian clocks coordinate metabolic events in response to light-dark and sleep-wake cycles. …

The composite human microbiome of Western populations has probably changed over the
past century, brought on by new environmental triggers that often have a negative impact on …

Neonatal necrotizing enterocolitis (NEC) is an inflammatory intestinal disorder affecting
preterm infants. Intestinal bacteria have an important function; however no causative pathogen …

Environmentally induced alterations in the commensal microbiota have been implicated in
the increasing prevalence of food allergy. We show here that sensitization to a food allergen …

I. Executive Summary Background The 5 years since the publication of the first International
Consensus Statement on Allergy and Rhinology: Rhinosinusitis (ICAR‐RS) has witnessed …

Inflammatory bowel diseases (IBD) develop via convergence of environmental, microbial,
immunological, and genetic factors. Alterations in the gut microbiota have been associated …

Lung disease causes most of the morbidity and mortality in cystic fibrosis (CF). Understanding
the pathogenesis of this disease has been hindered, however, by the lack of an animal …

Severe amyloidosis and plaque-localized neuro-inflammation are key pathological features
of Alzheimer’s disease (AD). In addition to astrocyte and microglial reactivity, emerging …