Melanin pigmentation protects the skin from the damaging effects of ultraviolet radiation (UVR).
There are two types of melanin, the red phaeome-lanin and the black eumelanin, both of …

The p53-regulated gene product p21 WAF1/CIP1 is the prototype of a family of small proteins
that negatively regulate the cell cycle. To learn more about p21 WAF1/CIP1 regulation in …

It is widely assumed that genes that influence variation in skin and hair pigmentation are
under selection. To date, the melanocortin 1 receptor (MC1R) is the only gene identified that …

Hailey–Hailey disease (HHD) is an autosomal dominant skin disorder characterized by
suprabasal cell separation (acantholysis) of the epidermis. Previous genetic linkage studies …

Melanocy stimulating hormone (MSH) plays an important role in determining the cutaneous
response to ultraviolet radiation and may also influence melanoma progression. We have …

Congenital melanocytic nevi (CMN) can be associated with neurological abnormalities and
an increased risk of melanoma. Mutations in NRAS, BRAF, and Tp53 have been described …

Variants of the melanocortin 1 receptor (MC1R) gene are common in individuals with red
hair and fair skin, but the relative contribution to these pigmentary traits in heterozygotes, …

Skin wound healing is a vital process that is important for re-establishing the epithelial barrier
following disease or injury. Aberrant or delayed skin wound healing increases the risk of …

The identification of an association between variants in the human melanocortin 1 receptor (MC1R)
gene and red hair and fair skin, as well as the relation between variants of this gene …

Ultraviolet radiation is a well established epidemiologic risk factor for malignant melanoma.
This observation has been linked to the relative resistance of normal melanocytes to …