Inhibition of the program of apoptosis has been reported to have little or no effect on clonogenic
survival after treatment with drugs or radiation in several tumor cell lines. A decrease in …

Exposure of human tumor cell lines to different chemotherapeutic drugs, ionizing radiation,
and differentiating agents induced morphological, enzymatic, and ploidy changes resembling …

Induction of cyclin-dependent kinase inhibitor p21 Waf1/Cip1/Sdi1 triggers cell growth
arrest associated with senescence and damage response. Overexpression of p21 from an …

Exposure of human tumor cell lines to moderate doses of anticancer agents induces terminal
proliferation arrest accompanied by morphologic and enzymatic changes that resemble …

Treatment with chemotherapy or radiation is not invariably cytotoxic to all tumor cells. Some
of the cells that survive treatment recover and resume proliferation, whereas others undergo …

ABCB1, also known as P-glycoprotein, actively extrudes xenobiotic compounds across the
plasma membrane of diverse cells, which contributes to cellular drug resistance and …

Conventional chemotherapy not only kills tumor cells but also changes gene expression in
treatment-damaged tissues, inducing production of multiple tumor-supporting secreted factors…

The multidrug transporter ABCB1 (P-glycoprotein) is an ATP-binding cassette transporter that
has a key role in protecting tissues from toxic insult and contributes to multidrug extrusion …

Induction of a cyclin-dependent kinase inhibitor p21 Waf1/Cip1/Sdi1 is an integral part of cell
growth arrest associated with senescence and damage response. p21 overexpression from …

Hormone therapy targeting estrogen receptor (ER) is the principal treatment for ER-positive
breast cancers. However, many cancers develop resistance to hormone therapy while …