Thresholds for thermal damage to normal tissues: an update

PS Yarmolenko, EJ Moon, C Landon… - International Journal …, 2011 - Taylor & Francis
The purpose of this review is to summarise a literature survey on thermal thresholds for
tissue damage. This review covers published literature for the consecutive years from 2002–2009…

[HTML][HTML] Targeting the lactate transporter MCT1 in endothelial cells inhibits lactate-induced HIF-1 activation and tumor angiogenesis

…, F Vegran, J Verrax, KM Kennedy, EJ Moon… - PloS one, 2012 - journals.plos.org
Switching to a glycolytic metabolism is a rapid adaptation of tumor cells to hypoxia.
Although this metabolic conversion may primarily represent a rescue pathway to meet the …

Effect of aerobic exercise on tumor physiology in an animal model of human breast cancer

…, MQ Potter, E Jung Moon… - Journal of applied …, 2010 - journals.physiology.org
Recent epidemiologic studies report that regular exercise may be associated with substantial
reductions in cancer-specific and all-cause mortality following a breast cancer diagnosis. …

Dual roles of NRF2 in tumor prevention and progression: possible implications in cancer treatment

EJ Moon, A Giaccia - Free Radical Biology and Medicine, 2015 - Elsevier
The cap’n’collar (CNC) family serves as cellular sensors of oxidative and electrophilic stresses
and shares structural similarities including basic leucine zipper (bZIP) and CNC domains. …

NADPH oxidase-mediated reactive oxygen species production activates hypoxia-inducible factor-1 (HIF-1) via the ERK pathway after hyperthermia treatment

EJ Moon, P Sonveaux, PE Porporato… - Proceedings of the …, 2010 - National Acad Sciences
Hyperthermia (HT) is a strong adjuvant treatment with radiotherapy and chemotherapy because
it causes tumor reoxygenation. However, the detailed molecular mechanisms of how HT …

[HTML][HTML] The HIF target MAFF promotes tumor invasion and metastasis through IL11 and STAT3 signaling

EJ Moon, SS Mello, CG Li, JT Chi, K Thakkar… - Nature …, 2021 - nature.com
Hypoxia plays a critical role in tumor progression including invasion and metastasis. To
determine critical genes regulated by hypoxia that promote invasion and metastasis, we screen …

The potential role of intrinsic hypoxia markers as prognostic variables in cancer

EJ Moon, DM Brizel, JTA Chi… - Antioxidants & redox …, 2007 - liebertpub.com
Tumor hypoxia is related to tumor progression and therapy resistance, which leads to poor
patient outcome. It has been suggested that measuring the hypoxic status of a tumor helps to …

Neutralization of PD-L2 is essential for overcoming immune checkpoint blockade resistance in ovarian cancer

…, TTC Yang, AN Diep, GM Cherf, Y Xu, EJ Moon… - Clinical cancer …, 2021 - AACR
Purpose: Ovarian cancer represents a major clinical hurdle for immune checkpoint blockade
(ICB), with reported low patient response rates. We found that the immune checkpoint …

The importance of hypoxia in radiotherapy for the immune response, metastatic potential and FLASH-RT

EJ Moon, K Petersson, MM Olcina - International journal of …, 2022 - Taylor & Francis
Purpose Hypoxia (low oxygen) is a common feature of solid tumors that has been intensely
studied for more than six decades. Here we review the importance of hypoxia to radiotherapy …

[HTML][HTML] Evaluation of salmon, tuna, and beef freshness using a portable spectrometer

EJ Moon, Y Kim, Y Xu, Y Na, AJ Giaccia, JH Lee - Sensors, 2020 - mdpi.com
There has been strong demand for the development of an accurate but simple method to
assess the freshness of food. In this study, we demonstrated a system to determine food …