Activation of neurotrophic factor signaling is a promising therapy for neurodegeneration.
However, the transient nature of ligand-dependent activation limits its effectiveness. In this study…

Dedicator of cytokinesis 3 (DOCK3) is an atypical member of the guanine nucleotide exchange
factors (GEFs) and plays important roles in neurite outgrowth. DOCK3 forms a complex …

Optic nerve injury induces optic nerve degeneration and retinal ganglion cell (RGC) death
that lead to visual disturbance. In this study, we examined if topical ripasudil has therapeutic …

Purpose To determine whether combination of topical ripasudil and brimonidine has more
effective neuroprotection on retinal ganglion cells (RGCs) following injury to axons composing …

Purpose: The present study aimed to examine the accuracy and availability of a novel
glaucoma visual field screening program using a head-mounted visual perimeter ‘imo.’ …

Purpose: To evaluate IOP by the day of the week. Patients and Methods: Annual health checkup
examinees between April 2014 and March 2015 were cross-sectionally evaluated. As a …

Purpose We conducted cross-sectional examinations to determine the frequency of peripapillary
retinoschisis (PRS) in eyes with glaucoma and suspected glaucoma and analyzed the …

Purpose To examine the variability in glaucoma screening using fundus images among
physicians, including non-ophthalmologists. Patients and Methods Sixty-nine eyes from 69 …

… Euido Nishijima and Masaharu Akiyama initially designed the concept of this work.
Mutsumi Koyama and Euido Nishijima collected and analyzed the patient data regarding the …

Visual disturbance after optic nerve injury is a serious problem. Attempts have been made to
enhance the intrinsic ability of retinal ganglion cells (RGCs) to regenerate their axons, and …