CPS1 maintains pyrimidine pools and DNA synthesis in KRAS/LKB1-mutant lung cancer cells
Metabolic reprogramming by oncogenic signals promotes cancer initiation and progression.
The oncogene KRAS and tumour suppressor STK11, which encodes the kinase LKB1, …
The oncogene KRAS and tumour suppressor STK11, which encodes the kinase LKB1, …
Organizational support and volunteering benefits for older adults
Purpose: This study tested a theoretical model of volunteering benefits and examined the
mechanism through which volunteering benefits older adults. Design and Methods: This is a 2-…
mechanism through which volunteering benefits older adults. Design and Methods: This is a 2-…
The activation mechanism of the insulin receptor: a structural perspective
The insulin receptor (IR) is a type II receptor tyrosine kinase that plays essential roles in
metabolism, growth, and proliferation. Dysregulation of IR signaling is linked to many human …
metabolism, growth, and proliferation. Dysregulation of IR signaling is linked to many human …
Activation mechanism of the insulin receptor revealed by cryo-EM structure of the fully liganded receptor–ligand complex
10.7554/eLife.48630.001 Insulin signaling controls metabolic homeostasis. Here, we report
the cryo-EM structure of full-length insulin receptor (IR) and insulin complex in the active state…
the cryo-EM structure of full-length insulin receptor (IR) and insulin complex in the active state…
[HTML][HTML] Insulin receptor endocytosis in the pathophysiology of insulin resistance
Insulin signaling controls cell growth and metabolic homeostasis. Dysregulation of this
pathway causes metabolic diseases such as diabetes. Insulin signaling pathways have been …
pathway causes metabolic diseases such as diabetes. Insulin signaling pathways have been …
[HTML][HTML] Structural basis of the activation of type 1 insulin-like growth factor receptor
Type 1 insulin-like growth factor receptor (IGF1R) is a receptor tyrosine kinase that regulates
cell growth and proliferation, and can be activated by IGF1, IGF2, and insulin. Here, we …
cell growth and proliferation, and can be activated by IGF1, IGF2, and insulin. Here, we …
Synergistic activation of the insulin receptor via two distinct sites
Insulin receptor (IR) signaling controls multiple facets of animal physiology. Maximally four
insulins bind to IR at two distinct sites, termed site-1 and site-2. However, the precise …
insulins bind to IR at two distinct sites, termed site-1 and site-2. However, the precise …
Why do older adult volunteers stop volunteering?
This paper reports a United States study of the factors that influence the turnover of older
adult volunteers. Based on a parent study of programmes that use older adult volunteers, the …
adult volunteers. Based on a parent study of programmes that use older adult volunteers, the …
BubR1 acetylation at prometaphase is required for modulating APC/C activity and timing of mitosis
Regulation of BubR1 is central to the control of APC/C activity. We have found that BubR1
forms a complex with PCAF and is acetylated at lysine 250. Using mass spectrometry and …
forms a complex with PCAF and is acetylated at lysine 250. Using mass spectrometry and …
Frailty and related outcomes in patients undergoing transcatheter valve therapies in a nationwide cohort
…, DS Pinto, LR Valsdottir, C Shen, E Choi… - European Heart …, 2019 - academic.oup.com
Aims We sought to identify the prevalence and related outcomes of frail individuals undergoing
transcatheter mitral valve repair and transcatheter aortic valve replacement (TAVR). …
transcatheter mitral valve repair and transcatheter aortic valve replacement (TAVR). …