Age‐related changes in hippocampal‐dependent synaptic plasticity and memory mediated by p75 neurotrophin receptor

LW Wong, YS Chong, W Lin, L Kisiswa, E Sim… - Aging …, 2021 - Wiley Online Library
The plasticity mechanisms in the nervous system that are important for learning and memory
are greatly impacted during aging. Notably, hippocampal‐dependent long‐term plasticity …

[HTML][HTML] CD137 negatively affects “browning” of white adipose tissue during cold exposure

…, A Moliner, ES Lee, E Nickles, E Sim… - Journal of Biological …, 2020 - ASBMB
Prolonged cold exposure stimulates the formation of brownlike adipocytes expressing UCP1
(uncoupling-protein-1) in subcutaneous white adipose tissue which, together with classical …

[HTML][HTML] AraC interacts with p75NTR transmembrane domain to induce cell death of mature neurons

V Lopes-Rodrigues, P Boxy, E Sim, DI Park… - Cell Death & …, 2023 - nature.com
Cytosine arabinoside (AraC) is one of the main therapeutic treatments for several types of
cancer, including acute myeloid leukaemia. However, after a high-dose AraC chemotherapy …

[HTML][HTML] Structural basis of NF-κB signaling by the p75 neurotrophin receptor interaction with adaptor protein TRADD through their respective death domains

N Zhang, L Kisiswa, A Ramanujan, Z Li, EW Sim… - Journal of Biological …, 2021 - ASBMB
The p75 neurotrophin receptor (p75 NTR ) is a critical mediator of neuronal death and tissue
remodeling and has been implicated in various neurodegenerative diseases and cancers. …

Sustained anti-obesity effects of life-style change and anti-inflammatory interventions after conditional inactivation of the activin receptor ALK7

RK Srivastava, ES Lee, E Sim, NC Sheng, CF Ibáñez - bioRxiv, 2020 - biorxiv.org
Life-style change and anti-inflammatory interventions have only transient effects in obesity.
It is not clear how benefits obtained by these treatments can be maintained longer term, …

Synthesis, X-ray structural and spectroscopic study of new silyl-substituted triosmium clusters

HG Ang, B Chang, WL Kwik, ESH Sim - Journal of organometallic chemistry, 1994 - Elsevier
The 2-pyridyldimethylsilane, 2-(CH 3 ) 2 SiHC 5 H 4 NLH reacts with Os 3 (μ-H) 2 (CO) 10 ]
to afford the novel cluster [Os 3 (μ-H) 2 (CO) 10 L 2 ] 1 in which each of the ligands L has …

Studying Abroad in Shanghai: Exploring How a Living-Learning Community Impacts Students' Sociocultural Understandings of China

S Erbes, R Jackson, E Sim - Journal of Higher Education Theory …, 2022 - articlearchives.co
This is a qualitative case study that explored how a study abroad program based in Shanghai
impacted five undergraduates’ sociocultural understandings of China. The purpose of this …

AraC binds the p75NTR transmembrane domain to induce neurodegeneration in mature neurons

V Lopes-Rodrigues, P Boxy, E Sim, DI Park… - bioRxiv, 2021 - biorxiv.org
Background Cytosine arabinoside (AraC) is one of the main therapeutic treatments for
several types of cancer including acute myeloid leukaemia. However, after high dose AraC …

Structural and functional elucidation of NF-κB signaling by the p75 neurotrophin receptor through recruitment of TRADD

N Zhang, L Kisiswa, A Ramanujan, Z Li, EW Sim… - bioRxiv, 2021 - biorxiv.org
p75 neurotrophin receptor (p75 NTR ) is a critical mediator of neuronal death and tissue
remodeling and has been implicated in various neurodegenerative diseases. The death domain …

Correction: Structural basis of NF-κB signaling by the p75 neurotrophin receptor interaction with adaptor protein TRADD through their respective death domains

N Zhang, L Kisiswa, A Ramanujan, Z Li, EW Sim… - Journal of Biological …, 2022 - ASBMB
The p75 neurotrophin receptor (p75 NTR) is a critical mediator of neuronal death and tissue
remodeling and has been implicated in various neurodegenerative diseases and cancers. …