User profiles for Eva Gil Iturbe

Eva Gil-Iturbe

Columbia University
Verified email at alumni.unav.es
Cited by 173

Mapping the genomic landscape of multidrug resistance in Plasmodium falciparum and its impact on parasite fitness

…, AY Burkhard, MR Ansbro, KJ Fairhurst, E Gil-Iturbe… - Science …, 2023 - science.org
Drug-resistant Plasmodium falciparum parasites have swept across Southeast Asia and now
threaten Africa. By implementing a P. falciparum genetic cross using humanized mice, we …

[HTML][HTML] Evidence for the early emergence of piperaquine-resistant Plasmodium falciparum malaria and modeling strategies to mitigate resistance

…, I Deni, J Kim, J Vendome, E Gil-Iturbe… - PLoS …, 2022 - journals.plos.org
Multidrug-resistant Plasmodium falciparum parasites have emerged in Cambodia and
neighboring countries in Southeast Asia, compromising the efficacy of first-line antimalarial …

Changes in brown adipose tissue lipid mediator signatures with aging, obesity, and DHA supplementation in female mice

E Félix‐Soriano, N Sáinz, E GilIturbe… - The FASEB …, 2021 - Wiley Online Library
Brown adipose tissue (BAT) dysfunction in aging and obesity has been related to chronic
unresolved inflammation, which could be mediated by an impaired production of specialized …

Subversion of serotonin receptor signaling in osteoblasts by kynurenine drives acute myeloid leukemia

M Galán-Díez, F Borot, AM Ali, J Zhao, E Gil-Iturbe… - Cancer discovery, 2022 - AACR
AML remains recalcitrant to treatments due to the emergence of resistant clones. We show a
leukemia-cell nonautonomous progression mechanism that involves activation of a …

[HTML][HTML] Differential remodeling of subcutaneous white and interscapular brown adipose tissue by long-term exercise training in aged obese female mice

E Félix-Soriano, N Sáinz, E Gil-Iturbe… - Journal of physiology …, 2023 - Springer
Obesity exacerbates aging-induced adipose tissue dysfunction. This study aimed to
investigate the effects of long-term exercise on inguinal white adipose tissue (iWAT) and …

[HTML][HTML] Effects of long-term DHA supplementation and physical exercise on non-alcoholic fatty liver development in obese aged female mice

J Yang, N Sáinz, E Félix-Soriano, E Gil-Iturbe… - Nutrients, 2021 - mdpi.com
Obesity and aging are associated to non-alcoholic fatty liver disease (NAFLD) development.
Here, we investigate whether long-term feeding with a docosahexaenoic acid (DHA)-…

[HTML][HTML] Mechanism of anion exchange and small-molecule inhibition of pendrin

L Wang, A Hoang, E Gil-Iturbe, A Laganowsky… - Nature …, 2024 - nature.com
Pendrin (SLC26A4) is an anion exchanger that mediates bicarbonate (HCO 3 − ) exchange
for chloride (Cl − ) and is crucial for maintaining pH and salt homeostasis in the kidney, lung, …

[HTML][HTML] Chronic docosahexaenoic acid supplementation improves metabolic plasticity in subcutaneous adipose tissue of aged obese female mice

…, N Sáinz, M Fernández-Galilea, E Gil-Iturbe… - The Journal of …, 2023 - Elsevier
This study aimed to characterize the potential beneficial effects of chronic docosahexaenoic
acid (DHA) supplementation on restoring subcutaneous white adipose tissue (scWAT) …

Additional PfCRT mutations driven by selective pressure for improved fitness can result in the loss of piperaquine resistance and altered Plasmodium falciparum …

…, A Willems, KA Schindler, GW Rangel, E Gil-Iturbe… - Mbio, 2024 - Am Soc Microbiol
Malaria elimination efforts in Southeast Asia have been hindered by multidrug-resistant
Plasmodium falciparum. High-grade resistance to piperaquine (PPQ, used in combination with …

Insight into the mechanism of H+-coupled nucleobase transport

…, Z Ren, K Chen, E Gil-Iturbe… - Proceedings of the …, 2023 - National Acad Sciences
Members of the nucleobase/ascorbic acid transporter (NAT) gene family are found in all
kingdoms of life. In mammals, the concentrative uptake of ascorbic acid (vitamin C) by members …