Dietary sphingomyelin (SM) inhibits early stages of colon cancer (appearance of aberrant
crypt foci, ACF) and decreases the proportion of adenocarcinomas vs. adenomas in 1,2-…

Alterations in the biomechanical properties and cytoskeletal organization of cancer cells in
addition to genetic changes have been correlated with their aggressive phenotype. In this …

Sphingolipids are hydrolyzed in the gastrointestinal tract to ceramide, sphingosine, and other
metabolites that can modulate cell growth, differentiation, and apoptosis. To characterize …

Sphingoid bases are growth inhibitory and pro-apoptotic for many types of cells when added
to cells exogenously, and can be elevated to toxic amounts endogenously when cells are …

The epidermal growth factor receptor (EGFR) is an oncogene frequently overexpressed in
breast cancer (BC), and its overexpression has been associated with poor prognosis and drug …

Dietary supplementation with milk sphingolipids inhibits colon tumorigenesis in CF1 mice
treated with a colon carcinogen [1,2-dimethylhydrazine (DMH)] and in multiple intestinal …

Fumonisin B 1 (FB 1 ) and aminopentol (AP 1 ) (which is formed by hydrolysis of FB 1 ) are
found in corn contaminated with some strains ofFusarium moniliforme.Incubation of HT29 …

This work is the first to demonstrate the ability of contactless dielectrophoresis (cDEP) to isolate
target cell species from a heterogeneous sample of live cells. Since all cell types have a …

Conjugated linoleic acid (CLA) exerts a protective effect on experimental inflammatory
bowel disease and shows promise as a chemopreventive agent against colorectal cancer (CRC) …

Sphingolipid consumption suppresses colon carcinogenesis, but the specific genetic defect(s)
that can be bypassed by these dietary components are not known. Colon tumors often …