The increasing complexity of readouts for omics analyses goes hand-in-hand with concerns
about the reproducibility of experiments that analyze'big data'1, 2, 3. When analyzing very …

The Rfam database (available at http://rfam.xfam.org ) is a collection of non-coding RNA
families represented by manually curated sequence alignments, consensus secondary …

Extracellular matrix (ECM) based biomaterials have an established place as medical
devices for wound healing and tissue regeneration. In the search for biomaterials we have …

The PSI/TM-Coffee web server performs multiple sequence alignment (MSA) of proteins by
combining homology extension with a consistency based alignment approach. Homology …

Ovine forestomach matrix (OFM) biomaterial acts as a biomimetic of native extracellular matrix
(ECM) by providing structural and functional cues to orchestrate cell activity during tissue …

Multiple sequence alignments (MSAs) are used for structural 1 , 2 and evolutionary
predictions 1 , 2 , but the complexity of aligning large datasets requires the use of approximate …

Ovine forestomach matrix (OFM) is a native and functional decellularized extracellular
matrix biomaterial that supports cell adhesion and proliferation and is remodeled during the …

Many fields of biology rely on the inference of accurate multiple sequence alignments (MSA)
of biological sequences. Unfortunately, the problem of assembling an MSA is NP-complete …

Phylogenetic reconstructions are essential in genomics data analyses and depend on accurate
multiple sequence alignment (MSA) models. We show that all currently available large-…

Motivation Most evolutionary analyses are based on pre-estimated multiple sequence
alignment. Wong et al. established the existence of an uncertainty induced by multiple sequence …