Liver cancer has the second highest worldwide cancer mortality rate and has limited
therapeutic options. We analyzed 363 hepatocellular carcinoma (HCC) cases by whole-exome …

DNA damage repair (DDR) pathways modulate cancer risk, progression, and therapeutic
response. We systematically analyzed somatic alterations to provide a comprehensive view of …

Diverse epidemiological factors are associated with hepatocellular carcinoma (HCC) prevalence
in different populations. However, the global landscape of the genetic changes in HCC …

Purpose: Aggressive cutaneous squamous cell carcinoma (cSCC) is often a disfiguring and
lethal disease. Very little is currently known about the mutations that drive aggressive cSCC. …

Cholangiocarcinoma (CCA) is an aggressive malignancy of the bile ducts, with poor
prognosis and limited treatment options. Here, we describe the integrated analysis of somatic …

Mutational processes constantly shape the somatic genome, leading to immunity, aging,
cancer, and other diseases. When cancer is the outcome, we are afforded a glimpse into these …

To understand the genetic drivers of immune recognition and evasion in colorectal cancer,
we analyzed 1,211 colorectal cancer primary tumor samples, including 179 classified as …

On the basis of multidimensional and comprehensive molecular characterization (including
DNA methalylation and copy number, RNA, and protein expression), we classified 894 renal …

Tumors with somatic mutations in the proofreading exonuclease domain of DNA polymerase
epsilon (POLE-exo*) exhibit a novel mutator phenotype, with markedly elevated TCT→TAT …

The ampulla of Vater is a complex cellular environment from which adenocarcinomas arise
to form a group of histopathologically heterogenous tumors. To evaluate the molecular …