Since the mid-1990s, dendritic cells have been used in clinical trials as cellular mediators for
therapeutic vaccination of patients with cancer. Dendritic cell-based immunotherapy is safe …

Active immunization using tumor antigen-loaded dendritic cells holds promise for the adjuvant
treatment of cancer to eradicate or control residual disease, but so far, most dendritic cell …

Over the past years, the phenotypic and functional boundaries distinguishing the main cell
subsets of the immune system have become increasingly blurred. In this respect, CD56 (also …

The Signal Transducer and Activator of Transcription (STAT) family of proteins consists of
transcription factors that play a complex and essential role in the regulation of physiologic cell …

Learning Objectives After completing this course, the reader should be able to: Describe the
subtypes of Toll-like receptor 7 and 8 agonists and their effect on the different components …

Dendritic cell (DC)-based vaccination for cancer treatment has seen considerable
development over recent decades. However, this field is currently in a state of flux toward niche-…

Breakthroughs in cancer immunotherapies have demonstrated considerable success, though
not without limitations. Non‐thermal plasma (NTP) for cancer therapy has been emerging …

A growing body of evidence points toward an important anti-cancer effect of bisphosphonates,
a group of inexpensive, safe, potent, and long-term stable pharmacologicals that are …

Relapse is a major problem in acute myeloid leukemia (AML) and adversely affects survival.
In this phase 2 study, we investigated the effect of vaccination with dendritic cells (DCs) …

Although cancer vaccination has yielded promising results in patients, the objective response
rates are low. The right choice of adjuvant might improve the efficacy. Here, we review the …