Amplification of the CCNE1 locus on chromosome 19q12 is prevalent in multiple tumour
types, particularly in high-grade serous ovarian cancer, uterine tumours and gastro-…

Solid-state NMR measurements performed on intact whole cells of Staphylococcus aureus
labeled selectively in vivo have established that des-N-methylleucyl oritavancin (which has …

The increasing frequency of Enterococcus faecium isolates with multidrug resistance is a
serious clinical problem given the severely limited number of therapeutic options available to …

Osteomyelitis is an infection located in bone and a notoriously difficult disease to manage,
requiring frequent and heavy doses of systemically administered antibiotics. Targeting …

PKMYT1 is a regulator of CDK1 phosphorylation and is a compelling therapeutic target for
the treatment of certain types of DNA damage response cancers due to its established …

Osteomyelitis is a difficult to treat bacterial infection of the bone. Delivering antibacterial
agents to the bone may overcome the difficulties in treating this illness by effectively …

The RNA polymerase holoenzyme is a proven target for antibacterial agents. A high-throughput
screening program based on this enzyme from Staphylococcus aureus had previously …

Glycopeptides whose aminosugars have been modified by attachment of hydrophobic side
chains are frequently active against vancomycin-resistant microorganisms. We have …

Enantiopure (3S,5R,8S)-3-[N-(Boc)amino]-1-azabicyclo[3.3.0]octan-2-one 8-carboxylic acid
(1) was synthesized in nine steps and 16% overall yield from aspartate β-aldehyde 7. …

As therapeutic agents of choice in the treatment of complicated infections, glycopeptide
antibiotics are often preferentially used in cases of osteomyelitis, an infection located in bone …