During their productive cycle, herpesviruses exhibit a strictly regulated temporal cascade of
gene expression that can be divided into three general stages: immediate-early (IE), early (E)…

The splicing machinery which positions a protein export complex near the exon-exon junction
mediates nuclear export of mRNAs generated from intron-containing genes. Many Epstein-…

Following infection by Epstein-Barr virus (EBV), the production of viral nuclear proteins
EBNA1, EBNA2, EBNA3A, and EBNA3C and the viral membrane protein LMP1 is essential for …

During their productive cycle, herpesviruses exhibit a strictly regulated temporal cascade of
gene expression that has three general stages: immediate early (IE), early (E), and late (L). …

The Epstein-Barr virus early protein EB2 (also called BMLF1, Mta, or SM), a protein absolutely
required for the production of infectious virions, shares properties with mRNA export …

In cells latently infected with EBV, the switch from latency to productive infection is linked to
the expression of two EBV“ transcription factors called EB1 (or Z) and R. EB1 is an upstream …

The stimulation of TLRs by pathogen-derived molecules leads to the production of proinflammatory
cytokines. Because uncontrolled inflammation can be life threatening, TLR regulation …

The presence of the Epstein-Barr virus (EBV)-encoded nuclear antigen-1 (EBNA1) protein
in all EBV-carrying tumours constitutes a marker that distinguishes the virus-associated …

That the expression of late genes is coupled to viral genome replication is well established
for all herpesviruses, but the exact mechanisms of their regulation, especially by viral proteins…

EBV infects most of the human population and is associated with a number of human diseases
including cancers. Moreover, evasion of the immune system and chronic infection is an …