Enhancers control the correct temporal and cell-type-specific activation of gene expression
in multicellular eukaryotes. Knowing their properties, regulatory activity and targets is crucial …

Active human promoters produce promoter-upstream transcripts (PROMPTs). Why these
RNAs are coupled to decay, whereas their neighboring promoter-downstream mRNAs are not, …

Nuclear processing and quality control of eukaryotic RNA is mediated by the RNA exosome,
which is regulated by accessory factors. However, the mechanism of exosome recruitment …

Splicing efficiency varies among transcripts, and tight control of splicing kinetics is crucial for
coordinated gene expression. N-6-methyladenosine (m6A) is the most abundant RNA …

Increasing brown adipose tissue (BAT) thermogenesis in mice and humans improves metabolic
health and understanding BAT function is of interest for novel approaches to counteract …

The systemic immune response to viral infection is shaped by master transcription factors,
such as NF-κB, STAT1, or PU.1. Although long noncoding RNAs (lncRNAs) have been …

The exonuclease torpedo Xrn2 loads onto nascent RNA 5′-PO 4 ends and chases down
pol II to promote termination downstream from polyA sites. We report that Xrn2 is recruited to …

Long non-coding RNAs (ncRNA) have recently been demonstrated to be expressed from a
subset of enhancers and to be required for the distant regulation of gene expression. Several …

Developmental genes such as Xist, which initiates X chromosome inactivation, are controlled
by complex cis-regulatory landscapes, which decode multiple signals to establish specific …

Tight regulation of gene expression is orchestrated by enhancers. Through recent research
advancements, it is becoming clear that enhancers are not solely distal regulatory elements …