User profiles for Evgenia Ntini
Evgenia NtiniMPI-MG, Berlin Verified email at molgen.mpg.de Cited by 3822 |
An atlas of active enhancers across human cell types and tissues
Enhancers control the correct temporal and cell-type-specific activation of gene expression
in multicellular eukaryotes. Knowing their properties, regulatory activity and targets is crucial …
in multicellular eukaryotes. Knowing their properties, regulatory activity and targets is crucial …
Polyadenylation site–induced decay of upstream transcripts enforces promoter directionality
Active human promoters produce promoter-upstream transcripts (PROMPTs). Why these
RNAs are coupled to decay, whereas their neighboring promoter-downstream mRNAs are not, …
RNAs are coupled to decay, whereas their neighboring promoter-downstream mRNAs are not, …
The human cap-binding complex is functionally connected to the nuclear RNA exosome
…, MS Kristiansen, H Storvall, E Ntini… - Nature structural & …, 2013 - nature.com
Nuclear processing and quality control of eukaryotic RNA is mediated by the RNA exosome,
which is regulated by accessory factors. However, the mechanism of exosome recruitment …
which is regulated by accessory factors. However, the mechanism of exosome recruitment …
[PDF][PDF] Transient N-6-methyladenosine transcriptome sequencing reveals a regulatory role of m6A in splicing efficiency
Splicing efficiency varies among transcripts, and tight control of splicing kinetics is crucial for
coordinated gene expression. N-6-methyladenosine (m6A) is the most abundant RNA …
coordinated gene expression. N-6-methyladenosine (m6A) is the most abundant RNA …
[HTML][HTML] LincRNA H19 protects from dietary obesity by constraining expression of monoallelic genes in brown fat
Increasing brown adipose tissue (BAT) thermogenesis in mice and humans improves metabolic
health and understanding BAT function is of interest for novel approaches to counteract …
health and understanding BAT function is of interest for novel approaches to counteract …
Single-cell RNA sequencing uncovers the nuclear decoy lincRNA PIRAT as a regulator of systemic monocyte immunity during COVID-19
…, D Wendisch, P Georg, E Ntini… - Proceedings of the …, 2022 - National Acad Sciences
The systemic immune response to viral infection is shaped by master transcription factors,
such as NF-κB, STAT1, or PU.1. Although long noncoding RNAs (lncRNAs) have been …
such as NF-κB, STAT1, or PU.1. Although long noncoding RNAs (lncRNAs) have been …
Xrn2 substrate mapping identifies torpedo loading sites and extensive premature termination of RNA pol II transcription
…, B Erickson, N Fong, SJ Pradhan, E Ntini… - Genes & …, 2022 - genesdev.cshlp.org
The exonuclease torpedo Xrn2 loads onto nascent RNA 5′-PO 4 ends and chases down
pol II to promote termination downstream from polyA sites. We report that Xrn2 is recruited to …
pol II to promote termination downstream from polyA sites. We report that Xrn2 is recruited to …
Long ncRNA expression associates with tissue-specific enhancers
Long non-coding RNAs (ncRNA) have recently been demonstrated to be expressed from a
subset of enhancers and to be required for the distant regulation of gene expression. Several …
subset of enhancers and to be required for the distant regulation of gene expression. Several …
[PDF][PDF] Distal and proximal cis-regulatory elements sense X chromosome dosage and developmental state at the Xist locus
…, L Brandenburg, I Dunkel, C Vechiatto, E Ntini… - Molecular Cell, 2022 - cell.com
Developmental genes such as Xist, which initiates X chromosome inactivation, are controlled
by complex cis-regulatory landscapes, which decode multiple signals to establish specific …
by complex cis-regulatory landscapes, which decode multiple signals to establish specific …
Functional impacts of non-coding RNA processing on enhancer activity and target gene expression
Tight regulation of gene expression is orchestrated by enhancers. Through recent research
advancements, it is becoming clear that enhancers are not solely distal regulatory elements …
advancements, it is becoming clear that enhancers are not solely distal regulatory elements …