Angiotensin-converting enzyme 2 (ACE2) and accessory proteases (TMPRSS2 and CTSL)
are needed for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) cellular entry…

The hallmark of Salmonella Typhimurium infection is an acute intestinal inflammatory
response, which is mediated through the action of secreted bacterial effector proteins. The pro-…

The COVID-19 pandemic, caused by the novel coronavirus SARS-CoV-2, creates an urgent
need for identifying molecular mechanisms that mediate viral entry, propagation, and tissue …

Hepatocarcinogenesis is a stepwise process. It involves several genetic and epigenetic
alterations, eg, loss of tumor suppressor gene expression (TP53, PTEN, RB) as well as …

Ubiquitination serves as a critical signal in the host immune response to infection. Many
pathogens have evolved strategies to exploit the ubiquitin (Ub) system to promote their own …

Multimodal measurements of single-cell profiles are proving increasingly useful for characterizing
cell states and regulatory mechanisms. In the present study, we developed PHAGE-…

Selective autophagy is mediated by the interaction of autophagy modifiers and autophagy
receptors that also bind to ubiquitinated cargo. Optineurin is an autophagy receptor that plays …

Understanding gene function and regulation in homeostasis and disease requires knowledge
of the cellular and tissue contexts in which genes are expressed. Here, we applied four …

Selected long noncoding RNAs (lncRNAs) have been shown to play important roles in
carcinogenesis. Although the cellular functions of these transcripts can be diverse, many lncRNAs …

Pathogenic mutations in mitochondrial DNA (mtDNA) compromise cellular metabolism,
contributing to cellular heterogeneity and disease. Diverse mutations are associated with diverse …