deep orange and carnation are two of the classic eye color genes in Drosophila. Here, we
demonstrate that Deep orange is part of a protein complex that localizes to endosomal …

Many developing tissues require programmed cell death (PCD) for proper formation. In mice
and C. elegans, developmental PCD is regulated by the Bcl‐2 family of proteins. Two bcl‐2 …

Repetitive elements, including LINE-1 (L1), comprise approximately half of the human genome.
These elements can potentially destabilize the genome by initiating their own replication …

Proteins that constitute the endosomal sorting complex required for transport (ESCRT) are
necessary for the sorting of proteins into multivesicular bodies (MVBs) and the budding of …

Cinnamon extract has been reported to have positive effects in fruit fly and mouse models
for Alzheimer’s disease (AD). However, cinnamon contains numerous potential active …

The Inhibitor of apoptosis (IAP) antagonists Reaper (Rpr), Grim and Hid are central regulators
of developmental apoptosis in Drosophila. Ectopic expression of each is sufficient to …

Huntington’s disease (HD) is a dominant, late-onset disease characterized by choreiform
movements, cognitive decline, and personality disturbance. It is caused by a polyglutamine …

Background The root extract of Rhodiola rosea has historically been used in Europe and
Asia as an adaptogen, and similar to ginseng and Shisandra, shown to display numerous …

In the developing compound eye of Drosophila, neuronal differentiation of the R7 photoreceptor
cell is induced by the interaction of the receptor tyrosine kinase Sevenless with its ligand …

Purpose [ 18 F]Mefway is a novel radiotracer specific to the serotonin 5-HT 1A receptor class.
In preparation for using this tracer in humans, we have performed whole-body PET studies …