Entry into mitosis is accompanied by profound changes in cortical actomyosin organization.
Here, we delineate a pathway downstream of the RhoGEF Pbl/Ect2 that directs this process …

Polarized epithelia develop distinct cell surface domains, with the apical membrane acquiring
characteristic morphological features such as microvilli. Cell polarization is driven by …

The SARS-CoV-2 pandemic has highlighted the need for improved technologies to help control
the spread of contagious pathogens. While rapid point-of-need testing plays a key role in …

Cdc42 regulates epithelial morphogenesis together with the Par complex (Baz/Par3-Par6-aPKC),
Crumbs (Crb/CRB3) and Stardust (Sdt/PALS1). However, how these proteins work …

Chorioamnionitis frequently induces a fetal inflammatory response syndrome (FIRS),
characterized by an elevation of proinflammatory mediators and systemic inflammation. Although …

Objective: To better understand the inflammatory response in the central nervous system (CNS)
after lipopolysaccharide (LPS)-induced chorioamnionitis. Study Design: Fetal sheep …

The ability of epithelial cells to assemble into sheets relies on their zonula adherens (ZA), a
circumferential belt of adherens junction (AJ) material, which can be remodeled during …

Vulnerable pregnant women have an increased risk for preterm birth and perinatal mortality.
This study identifies the perspectives, perceived barriers, and perceived facilitators of …

Background Perinatal asphyxia (PA) is a major cause of brain damage and neurodevelopmental
impairment in infants. Recent investigations have shown that experimental sublethal …

In a rat model of global fetal and perinatal asphyxia, we investigated if asphyxia and long-lasting
brain tolerance to asphyxia (preconditioning) are mediated by modifications in …