[HTML][HTML] A panel of human neutralizing mAbs targeting SARS-CoV-2 spike at multiple epitopes

…, Y Yahalom-Ronen, M Israeli, E Epstein… - Nature …, 2020 - nature.com
The novel highly transmissible human coronavirus SARS-CoV-2 is the causative agent of the
COVID-19 pandemic. Thus far, there is no approved therapeutic drug specifically targeting …

Transcriptome and proteome analysis of Chinese hamster ovary cells under low temperature and butyrate treatment

A Kantardjieff, NM Jacob, JC Yee, E Epstein… - Journal of …, 2010 - Elsevier
Recombinant Chinese hamster ovary (CHO) cells selected for high productivity are capable
of secreting immunoglobulin G (IgG) molecules at a level that rivals plasma cells in vivo. …

[HTML][HTML] Post-exposure protection of SARS-CoV-2 lethal infected K18-hACE2 transgenic mice by neutralizing human monoclonal antibody

…, R Alcalay, R Falach, M Aftalion, E Epstein… - Nature …, 2021 - nature.com
The coronavirus disease 2019 (COVID-19) pandemic, caused by the severe acute respiratory
syndrome coronavirus 2 (SARS-CoV-2), exhibits high levels of mortality and morbidity and …

[HTML][HTML] Identification of SARS-CoV-2 receptor binding inhibitors by in vitro screening of drug libraries

…, N Natan, L Levin, S Chapman, LC Mimran, E Epstein… - Molecules, 2021 - mdpi.com
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is responsible for the
coronavirus disease 2019 (COVID-19) global pandemic. The first step of viral infection is cell …

[HTML][HTML] Spike vs nucleocapsid SARS-CoV-2 antigen detection: application in nasopharyngeal swab specimens

…, O Schuster, R Alcalay, E Makdasi, E Epstein… - Analytical and …, 2021 - Springer
Public health experts emphasize the need for quick, point-of-care SARS-CoV-2 detection as
an effective strategy for controlling virus spread. To this end, many “antigen” detection …

[PDF][PDF] Therapeutic antibodies, targeting the SARS-CoV-2 spike N-terminal domain, protect lethally infected K18-hACE2 mice

…, SL Ben-Arye, S Lazar, A Zauberman, E Epstein… - Iscience, 2021 - cell.com
Neutralizing antibodies represent a valuable therapeutic approach to countermeasure the
current COVID-19 pandemic. Emergence of SARS-CoV-2 variants emphasizes the notion that …

[HTML][HTML] Neutralizing monoclonal anti-SARS-CoV-2 antibodies isolated from immunized rabbits define novel vulnerable spike-protein epitope

…, T Noy-Porat, E Zahavy, A Mechaly, E Epstein… - Viruses, 2021 - mdpi.com
Monoclonal antibodies represent an important avenue for COVID-19 therapy and are routinely
used for rapid and accessible diagnosis of SARS-CoV-2 infection. The recent emergence …

[HTML][HTML] Isolation of anti-ricin protective antibodies exhibiting high affinity from immunized non-human primates

T Noy-Porat, R Rosenfeld, N Ariel, E Epstein, R Alcalay… - Toxins, 2016 - mdpi.com
Ricin, derived from the castor bean plant Ricinus communis, is one of the most potent and
lethal toxins known, against which there is no available antidote. To date, the use of …

Contribution of Immunological Memory to Protective Immunity Conferred by a Bacillus anthracis Protective Antigen-Based Vaccine

H Marcus, R Danieli, E Epstein, B Velan… - Infection and …, 2004 - Am Soc Microbiol
Protective antigen (PA)-based vaccination is an effective countermeasure to anthrax infection.
While neutralizing anti-PA antibody titers elicited by this vaccine serve as good correlates …

[HTML][HTML] Synergistic effect of two human-like monoclonal antibodies confers protection against orthopoxvirus infection

…, N Erez, S Weiss, R Rosenfeld, E Epstein… - Nature …, 2024 - nature.com
The eradication of smallpox was officially declared by the WHO in 1980, leading to
discontinuation of the vaccination campaign against the virus. Consequently, immunity against …