Cholesterol 25-hydroxylase (CH25H) is an interferon (IFN)-stimulated gene that shows
broad antiviral activities against a wide range of enveloped viruses. Here, using an IFN-…

As neurons die, cholesterol is released in the central nervous system (CNS); hence, this
sterol and its metabolites may represent a biomarker of neurodegeneration, including in …

Oxysterols are oxygenated forms of cholesterol or its precursors. They are formed enzymatically
and via reactive oxygen species. Oxysterols are intermediates in bile acid and steroid …

Every cell in vertebrates possesses the machinery to synthesise cholesterol and to
metabolise it. The major route of cholesterol metabolism is conversion to bile acids. Bile acids …

Despite being a critical molecule in the brain, mass spectrometry imaging (MSI) of cholesterol
has been under-reported compared to other lipids due to the difficulty in ionizing the sterol …

Dysregulated cholesterol metabolism is implicated in a number of neurological disorders.
Many sterols, including cholesterol and its precursors and metabolites, are biologically active …

In this short review we provide a synopsis of recent developments in oxysterol research
highlighting topics of current interest to the community. These include the involvement of …

Cholestane-3β,5α,6β-triol (3β,5α,6β-triol) is formed from cholestan-5,6-epoxide (5,6-EC) in a
reaction catalysed by cholesterol epoxide hydrolase, following formation of 5,6-EC through …

Cholesterolomics can be regarded as the identification and quantification of cholesterol, its
precursors post squalene, and metabolites of cholesterol and of its precursors, in a biological …

Using liquid chromatography – mass spectrometry in combination with derivatisation
chemistry we profiled the oxysterol and cholestenoic acid content of cerebrospinal fluid from …