… g | A sequence of diffraction-limited images of the same area as part f, where only few
molecules are ON simultaneously. h,i | In each frame, single molecules are computationally …

… (f) Visual comparison of 10-nm-grid DNA origami with predicted binding sites via (g)
Histogram … (f) Average image of 215 DNA origami with the letters 'LMU'. The mean number of …

INTRODUCTION Cells have evolved quality control mechanisms that operate under normal
growth conditions and during stress to maintain protein homeostasis (proteostasis) and …

… f, A model of a cuboid with the DNA-PAINT handles at its eight corners (black protrusions)
docked on a glass slide (blue shading) (top left) and 3D DNA-PAINT super-resolution images …

Synthetic polymers are ubiquitous in the modern world, but our ability to exert control over
the molecular conformation of individual polymers is very limited. In particular, although the …

… To test the compatibility of DNA-PAINT imaging with small molecule probes, we selected
phalloidin, a bicyclic heptapeptide, to selectively target F-actin. Actin filaments are usually …

… DNA-PAINT can also be used for 3D super-resolution imaging of 3D DNA origami structures
(Figure 2f). Additionally, as the imager strands only transiently bind to the docking strand, …

Single-molecule localization microscopy (SMLM) can visualize biological targets on the
nanoscale, but complex hardware is required to perform SMLM in thick samples. Here, we …

… , exposing an unstrained cryptic docking sequence when receptor force, F, exceeds the
probe F 1/2 , which is defined as the equilibrium F that produces a 50% probability of unfolding. …

Lipid metabolism is highly compartmentalized between cellular organelles that dynamically
adapt their compositions and interactions in response to metabolic challenges. Here, we …