The immune synapse is an exquisitely evolved means of communication between T cells and
antigen-presenting cells (APCs) during antigen recognition. Recent evidence points to the …

Exosomes are released by most cells to the extracellular environment and are involved in
cell-to-cell communication. Exosomes contain specific repertoires of mRNAs, microRNAs (…

Despite the plethora of methods available for the functional analysis of omics data, obtaining
comprehensive-yet detailed understanding of the results remains challenging. This is …

Human mitochondrial DNA (mtDNA) shows extensive within-population sequence variability
1 . Many studies suggest that mtDNA variants may be associated with ageing or diseases 2 …

10.7554/eLife.03696.001 Mesenchymal stem cells (MSCs) and osteolineage cells contribute
to the hematopoietic stem cell (HSC) niche in the bone marrow of long bones. However, …

RNA-binding proteins (RBPs) play a crucial role in key cellular processes, including RNA
transport, splicing, polyadenylation and stability. Understanding the interaction between RBPs …

Background Clonal hematopoiesis driven by somatic mutations in hematopoietic cells,
frequently called clonal hematopoiesis of indeterminate potential (CHIP), has been associated …

Birth presents a metabolic challenge to cardiomyocytes as they reshape fuel preference from
glucose to fatty acids for postnatal energy production 1 , 2 . This adaptation is triggered in …

Transcriptional and proteomic profiling of individual cells have revolutionized interpretation
of biological phenomena by providing cellular landscapes of healthy and diseased tissues 1 …

Objective: microRNAs are master regulators of gene expression with essential roles in
virtually all biological processes. miR-217 has been associated with aging and cellular …