The embryonic development of mammalian neural tube defects
AJ Copp, FA Brook, JP Estibeiro, ASW Shum… - Progress in …, 1990 - Elsevier
6.1. Embryonic mechanisms of NTD development 6.2. Genetics of NTD in mouse and
human Acknowledgements
human Acknowledgements
New cell lines from mouse epiblast share defining features with human embryonic stem cells
PJ Tesar, JG Chenoweth, FA Brook, TJ Davies… - Nature, 2007 - nature.com
The application of human embryonic stem (ES) cells in medicine and biology has an inherent
reliance on understanding the starting cell population. Human ES cells differ from mouse …
reliance on understanding the starting cell population. Human ES cells differ from mouse …
The origin and efficient derivation of embryonic stem cells in the mouse
FA Brook, RL Gardner - Proceedings of the National …, 1997 - National Acad Sciences
By explanting tissues isolated microsurgically from implanting strain 129 mouse blastocysts
individually on STO feeder cells we have established that embryonic stem (ES) cells …
individually on STO feeder cells we have established that embryonic stem (ES) cells …
[PDF][PDF] Reflections on the biology of embryonic stem (ES) cells.
RL Gardner, FA Brook - The International journal of developmental …, 1997 - ijdb.ehu.es
Remarkably little is known about mammalian embryonic stem (ES) cells despite their very
widespread use in studies on gene disruption and transgenesis. As yet, it is only in the mouse …
widespread use in studies on gene disruption and transgenesis. As yet, it is only in the mouse …
Embryonic stem cell-derived tissues are immunogenic but their inherent immune privilege promotes the induction of tolerance
NJ Robertson, FA Brook, RL Gardner… - Proceedings of the …, 2007 - National Acad Sciences
Although human embryonic stem (ES) cells may one day provide a renewable source of
tissues for cell replacement therapy (CRT), histoincompatibility remains a significant barrier to …
tissues for cell replacement therapy (CRT), histoincompatibility remains a significant barrier to …
[HTML][HTML] Directed differentiation of dendritic cells from mouse embryonic stem cells
Dendritic cells (DCs) are uniquely capable of presenting antigen to naive T cells, either
eliciting immunity [1] or ensuring self-tolerance [2]. This property identifies DCs as potential …
eliciting immunity [1] or ensuring self-tolerance [2]. This property identifies DCs as potential …
A cell-type-specific abnormality of cell proliferation in mutant (curly tail) mouse embryos developing spinal neural tube defects
AJ Copp, FA Brook, HJ Roberts - Development, 1988 - journals.biologists.com
The mouse mutant curly tail (ct) provides a model system for studies of neurulation mechanisms.
60 % of ct/ct embryos develop spinal neural tube defects (NTD) as a result of delayed …
60 % of ct/ct embryos develop spinal neural tube defects (NTD) as a result of delayed …
Measurement of myofilament-localized calcium dynamics in adult cardiomyocytes and the effect of hypertrophic cardiomyopathy mutations
…, S Patel, YF Chang, CN Broyles, FA Brook… - Circulation …, 2019 - Am Heart Assoc
Rationale: Subcellular Ca 2+ indicators have yet to be developed for the myofilament where
disease mutation or small molecules may alter contractility through myofilament Ca 2+ …
disease mutation or small molecules may alter contractility through myofilament Ca 2+ …
[HTML][HTML] Comparing the effects of chemical Ca2+ dyes and R-GECO on contractility and Ca2+ transients in adult and human iPSC cardiomyocytes
…, JN Simon, CN Broyles, YF Chang, FA Brook… - Journal of Molecular and …, 2023 - Elsevier
We compared commonly used BAPTA-derived chemical Ca 2+ dyes (fura2, Fluo-4, and Rhod-2)
with a newer genetically encoded indicator (R-GECO) in single cell models of the heart. …
with a newer genetically encoded indicator (R-GECO) in single cell models of the heart. …
Does lumbosacral spina bifida arise by failure of neural folding or by defective canalisation?
AJ Copp, FA Brook - Journal of medical genetics, 1989 - jmg.bmj.com
… Copp AJ, Crolla JA, Brook FA. Prevention of spinal neural tube defects in the mouse
embryo by growth retardation during neurulation. Development 1988;104:297-303. …
embryo by growth retardation during neurulation. Development 1988;104:297-303. …