User profiles for F. A. Pennacchio

Fabrizio Andrea Pennacchio

Group Lead, ETH
Verified email at hest.ethz.ch
Cited by 311

[HTML][HTML] Tailoring cellular function: the contribution of the nucleus in mechanotransduction

FA Pennacchio, P Nastały, A Poli… - … in Bioengineering and …, 2021 - frontiersin.org
Cells sense a variety of different mechanochemical stimuli and promptly react to such signals
by reshaping their morphology and adapting their structural organization and tensional …

[HTML][HTML] PIP4K2B is mechanoresponsive and controls heterochromatin-driven nuclear softening through UHRF1

A Poli, FA Pennacchio, A Ghisleni… - Nature …, 2023 - nature.com
… Kinase (FAK) phosphorylation, a marker of FA assembly, by western blotting in cells silenced
for … In line with our findings, IF analyses showed impairment of FA and actin cytoskeleton …

[HTML][HTML] Tissue fluidification promotes a cGAS–STING cytosolic DNA response in invasive breast cancer

…, K Havas, S Magni, Z Lavagnino, FA Pennacchio… - Nature materials, 2023 - nature.com
The process in which locally confined epithelial malignancies progressively evolve into
invasive cancers is often promoted by unjamming, a phase transition from a solid-like to a liquid-…

[HTML][HTML] Non-invasive production of multi-compartmental biodegradable polymer microneedles for controlled intradermal drug release of labile molecules

…, R Vecchione, C Casale, FA Pennacchio… - … in bioengineering and …, 2019 - frontiersin.org
Transdermal drug delivery represents an appealing alternative to conventional drug administration
systems. In fact, due to their high patient compliance, the development of dissolvable …

Three-dimensionally patterned scaffolds modulate the biointerface at the nanoscale

FA Pennacchio, F Caliendo, G Iaccarino, A Langella… - Nano …, 2019 - ACS Publications
The main aim of cell instructive materials is to guide in a controlled way cellular behavior by
fine-tuning cell-material crosstalk. In the last decades, several efforts have been spent in …

Electron microscopy for 3D scaffolds–cell biointerface characterization

D Iandolo, FA Pennacchio, V Mollo… - Advanced …, 2019 - Wiley Online Library
Cell fate is largely determined by interactions that occur at the interface between cells and
their surrounding microenvironment. For this reason, especially in the field of tissue‐…

Three-dimensional microstructured azobenzene-containing gelatin as a photoactuable cell confining system

FA Pennacchio, C Fedele, S De Martino… - … applied materials & …, 2018 - ACS Publications
In materials science, there is a considerable interest in the fabrication of highly engineered
biomaterials that can interact with cells and control their shape. In particular, from the literature…

Bioelectronics goes 3D: new trends in cell–chip interface engineering

FA Pennacchio, LD Garma, L Matino… - Journal of Materials …, 2018 - pubs.rsc.org
Bioelectronic platforms can be used for electrophysiology, monitoring and stimulating specific
cellular functions. While planar electroactive materials have been extensively used, in the …

[HTML][HTML] N2FXm, a method for joint nuclear and cytoplasmic volume measurements, unravels the osmo-mechanical regulation of nuclear volume in mammalian cells

FA Pennacchio, A Poli, FM Pramotton, S Lavore… - Nature …, 2024 - nature.com
In eukaryotes, cytoplasmic and nuclear volumes are tightly regulated to ensure proper cell
homeostasis. However, current methods to measure cytoplasmic and nuclear volumes, …

[HTML][HTML] The transcription factor PREP1 (PKNOX1) regulates nuclear stiffness, the expression of LINC complex proteins and mechanotransduction

…, FM Pramotton, R Choudhary, FA Pennacchio… - Communications …, 2022 - nature.com
… However, this result is opposed to PREP1 depleted cells where increased FA signaling and
actin fibers did not favor nuclear translocation of YAP. These data again showed that cellular …