User profiles for F. C. MacKintosh

Fred C MacKintosh

Rice University
Verified email at rice.edu
Cited by 30527

Modeling semiflexible polymer networks

CP Broedersz, FC MacKintosh - Reviews of Modern Physics, 2014 - APS
… CP Broedersz and FC MacKintosh: Modeling semiflexible … CP Broedersz and FC MacKintosh:
Modeling semiflexible … CP Broedersz and FC MacKintosh: Modeling semiflexible polymer …

Microrheology

FC MacKintosh, CF Schmidt - Current opinion in colloid & interface science, 1999 - Elsevier
Several complementary techniques have been developed in recent years that make it possible
to measure viscoelastic properties of soft materials on micrometer scales. Such methods …

Intracellular transport by active diffusion

CP Brangwynne, GH Koenderink, FC MacKintosh… - Trends in cell …, 2009 - cell.com
All substances exhibit constant random motion at the microscopic scale. This is a direct
consequence of thermal agitation, and leads to diffusion of molecules and small particles in a …

Nonlinear elasticity in biological gels

C Storm, JJ Pastore, FC MacKintosh, TC Lubensky… - Nature, 2005 - nature.com
The mechanical properties of soft biological tissues are essential to their physiological function
and cannot easily be duplicated by synthetic materials. Unlike simple polymer gels, many …

Elastic behavior of cross-linked and bundled actin networks

ML Gardel, JH Shin, FC MacKintosh, L Mahadevan… - Science, 2004 - science.org
Networks of cross-linked and bundled actin filaments are ubiquitous in the cellular cytoskeleton,
but their elasticity remains poorly understood. We show that these networks exhibit …

Elasticity of semiflexible biopolymer networks

FC MacKintosh, J Käs, PA Janmey - Physical review letters, 1995 - APS
We develop a model for cross-linked gels and sterically entangled solutions of semiflexible
biopolymers such as F-actin. Such networks play a crucial structural role in the cytoskeleton …

Nonequilibrium mechanics of active cytoskeletal networks

D Mizuno, C Tardin, CF Schmidt, FC MacKintosh - Science, 2007 - science.org
Cells both actively generate and sensitively react to forces through their mechanical framework,
the cytoskeleton, which is a nonequilibrium composite material including polymers and …

Microtubules can bear enhanced compressive loads in living cells because of lateral reinforcement

CP Brangwynne, FC MacKintosh, S Kumar… - The Journal of cell …, 2006 - rupress.org
Cytoskeletal microtubules have been proposed to influence cell shape and mechanics
based on their ability to resist large-scale compressive forces exerted by the surrounding …

Tuning bilayer twist using chiral counterions

R Oda, I Huc, M Schmutz, SJ Candau, FC MacKintosh - Nature, 1999 - nature.com
From seashells to DNA, chirality is expressed at every level of biological structures. In self-assembled
structures it may emerge cooperatively from chirality at the molecular scale. …

Scanning probe-based frequency-dependent microrheology of polymer gels and biological cells

RE Mahaffy, CK Shih, FC MacKintosh, J Käs - Physical review letters, 2000 - APS
A new scanning probe-based microrheology approach is used to quantify the frequency-dependent
viscoelastic behavior of both fibroblast cells and polymer gels. The scanning probe …