In most eukaryotes, poly (ADP-ribose) polymerase (PARP) recognizes DNA strand interruptions
generated in vivo. DNA binding by PARP triggers primarily its own modification by the …

… We thank all Fd’AdF laboratory members for discussions. FR is supported by Fondazione
Italiana per la Ricerca sul Cancro (FIRC, application number 12476). UH laboratory is …

… Fd'AdF conceived the project. NM, AM, Fd'AdF and MPL conceived and designed the
experiments. NM, CT, MW, MM and DC performed the experiments. NM, CT, MW, MD, AM, Fd'AdF …

Telomeres, the ends of eukaryotic chromosomes, play a central role in the control of cellular
senescence and organismal ageing and need to be protected in order to avoid being …

Oncogene-induced reactive oxygen species (ROS) have been proposed to be signaling
molecules that mediate proliferative cues. However, ROS may also cause DNA damage and …

Transcription has classically been considered a potential threat to genome integrity. Collision
between transcription and DNA replication machinery, and retention of DNA:RNA hybrids, …

The causal role of aneuploidy in cancer initiation remains under debate since mutations of
euploidy‐controlling genes reduce cell fitness but aneuploidy strongly associates with human …

The DNA damage response (DDR) is activated upon DNA damage generation to promote
DNA repair and inhibit cell cycle progression in the presence of a lesion. Cellular senescence …

The DNA damage response (DDR) signal transduction pathway is responsible for sensing
DNA damage and further relaying this signal into the cell. ATM is an apical DDR kinase that …

Background The overall survival of mCRC patients has been increased by the availability of
new cytotoxic and targeted agents and today potentially by the advent of immunotherapies. …