Over the past decade, cross-linking mass spectrometry (CLMS) has developed into a robust
and flexible tool that provides medium-resolution structural information. CLMS data provide …

Cross-linking mass spectrometry has become an established technology to provide structural
information on the topology and dynamics of protein complexes. Readily accessible …

Structural biology studies performed inside cells can capture molecular machines in action
within their native context. In this work, we developed an integrative in-cell structural …

Newly made mRNAs are processed and packaged into mature ribonucleoprotein complexes
(mRNPs) and are recognized by the essential transcription–export complex (TREX) for …

We show that the M2 isoform of pyruvate kinase (M2PYK) exists in equilibrium between
monomers and tetramers regulated by allosteric binding of naturally occurring small-molecule …

Identifying all essential genomic components is critical for the assembly of minimal artificial
life. In the genome‐reduced bacterium Mycoplasma pneumoniae, we found that small ORF s (…

We present a concise workflow to enhance the mass spectrometric detection of crosslinked
peptides by introducing sequential digestion and the crosslink identification software xi …

Complexes containing a pair of structural maintenance of chromosomes (SMC) family proteins
are fundamental for the three-dimensional (3D) organization of genomes in all domains of …

The number of publications in the field of chemical cross-linking combined with mass spectrometry
(XL-MS) to derive constraints for protein three-dimensional structure modeling and to …

Structural maintenance of chromosomes (SMC)–kleisin complexes organize chromosomal
DNAs in all domains of life, with key roles in chromosome segregation, DNA repair and …