Keap1 is a highly redox-sensitive member of the BTB-Kelch family that assembles with the
Cul3 protein to form a Cullin–RING E3 ligase complex for the degradation of Nrf2. Oxidative …

The highly diverse Numb-associated kinase (NAK) family has been linked to broad cellular
functions including receptor-mediated endocytosis, Notch pathway modulation, osteoblast …

Herein, we describe a systematic SAR‐ and SPR‐investigation of the peptidomimetic
hydroxy‐proline based VHL‐ligand VH032, from which most to‐date published VHL‐targeting …

Members of the potassium channel tetramerization domain (KCTD) family are soluble non-channel
proteins that commonly function as Cullin3 (Cul3)-dependent E3 ligases. Solution …

β-Catenin-dependent WNT signal transduction governs development, tissue homeostasis,
and a vast array of human diseases. Signal propagation through a WNT-Frizzled/LRP …

WNK1 [with no lysine (K)] and WNK4 regulate blood pressure by controlling the activity of
ion co-transporters in the kidney. Groundbreaking work has revealed that the ubiquitylation …

There are currently no approved drugs for the treatment of emerging viral infections, such as
dengue and Ebola. Adaptor-associated kinase 1 (AAK1) is a cellular serine–threonine …

The anthrax protein protective antigen (PA) is responsible for cell-surface recognition and
aids the delivery of the toxic anthrax enzymes into host cells. By targeting PA and preventing it …

Polymorphisms in the region of the calmodulin-dependent kinase isoform D (CaMK1D) gene
are associated with increased incidence of diabetes, with the most common polymorphism …

Abstract Structure–activity relationships within the indole‐3‐glyoxylamide series of antiprion
agents have been explored further, resulting in discovery of several new compounds …