User profiles for F. S. Gazzaniga
Francesca GazzanigaPrincipal Investigator in Pathology at Massachusetts General Hospital, Instructor in … Verified email at hms.harvard.edu Cited by 1967 |
A complex human gut microbiome cultured in an anaerobic intestine-on-a-chip
S Jalili-Firoozinezhad, FS Gazzaniga… - Nature biomedical …, 2019 - nature.com
The diverse bacterial populations that comprise the commensal microbiome of the human
intestine play a central role in health and disease. A method that sustains complex microbial …
intestine play a central role in health and disease. A method that sustains complex microbial …
[HTML][HTML] Microbiota-dependent regulation of costimulatory and coinhibitory pathways via innate immune sensors and implications for immunotherapy
Our bodies are inhabited by trillions of microorganisms. The host immune system constantly
interacts with the microbiota in barrier organs, including the intestines. Over decades, …
interacts with the microbiota in barrier organs, including the intestines. Over decades, …
Heterogeneous dysregulation of microRNAs across the autism spectrum
K Abu-Elneel, T Liu, FS Gazzaniga, Y Nishimura… - neurogenetics, 2008 - Springer
microRNAs (miRNAs) are ~21 nt transcripts capable of regulating the expression of many
mRNAs and are abundant in the brain. miRNAs have a role in several complex diseases …
mRNAs and are abundant in the brain. miRNAs have a role in several complex diseases …
Targeting PD-L2–RGMb overcomes microbiome-related immunotherapy resistance
The gut microbiota is a crucial regulator of anti-tumour immunity during immune checkpoint
inhibitor therapy. Several bacteria that promote an anti-tumour response to immune …
inhibitor therapy. Several bacteria that promote an anti-tumour response to immune …
The major reverse transcriptase–incompetent splice variant of the human telomerase protein inhibits telomerase activity but protects from apoptosis
I Listerman, J Sun, FS Gazzaniga, JL Lukas… - Cancer research, 2013 - AACR
Human telomerase reverse transcriptase (hTERT; the catalytic protein subunit of telomerase)
is subjected to numerous alternative splicing events, but the regulation and function of …
is subjected to numerous alternative splicing events, but the regulation and function of …
Microbial transmission in the social microbiome and host health and disease
Although social interactions are known to drive pathogen transmission, the contributions of
socially transmissible host-associated mutualists and commensals to host health and disease …
socially transmissible host-associated mutualists and commensals to host health and disease …
Gut microbial fatty acid isomerization modulates intraepithelial T cells
…, B Bao, SS Mello, X Sun, W Zheng, FS Gazzaniga… - Nature, 2023 - nature.com
The human gut microbiome constantly converts natural products derived from the host and
diet into numerous bioactive metabolites 1 , 2 – 3 . Dietary fats are essential micronutrients …
diet into numerous bioactive metabolites 1 , 2 – 3 . Dietary fats are essential micronutrients …
Symbionts exploit complex signaling to educate the immune system
The mammalian immune system is tolerized to trillions of microbes residing on bodily
surfaces and can discriminate between symbionts and pathogens despite their having related …
surfaces and can discriminate between symbionts and pathogens despite their having related …
An antiapoptotic role for telomerase RNA in human immune cells independent of telomere integrity or telomerase enzymatic activity
FS Gazzaniga, EH Blackburn - Blood, The Journal of the …, 2014 - ashpublications.org
Telomerase is a ribonucleoprotein complex that adds telomeric DNA to the ends of linear
chromosomes. It contains two core canonical components: the essential RNA component, hTR, …
chromosomes. It contains two core canonical components: the essential RNA component, hTR, …
An investigation of the effects of the core protein telomerase reverse transcriptase on Wnt signaling in breast cancer cells
I Listerman, FS Gazzaniga… - Molecular and cellular …, 2014 - Taylor & Francis
Telomerase canonically maintains telomeres, but recent reports have suggested that the core
protein mammalian telomerase reverse transcriptase (TERT) component, together with the …
protein mammalian telomerase reverse transcriptase (TERT) component, together with the …