User profiles for F. S. Gazzaniga

Francesca Gazzaniga

Principal Investigator in Pathology at Massachusetts General Hospital, Instructor in …
Verified email at hms.harvard.edu
Cited by 1967

A complex human gut microbiome cultured in an anaerobic intestine-on-a-chip

S Jalili-Firoozinezhad, FS Gazzaniga… - Nature biomedical …, 2019 - nature.com
The diverse bacterial populations that comprise the commensal microbiome of the human
intestine play a central role in health and disease. A method that sustains complex microbial …

[HTML][HTML] Microbiota-dependent regulation of costimulatory and coinhibitory pathways via innate immune sensors and implications for immunotherapy

JS Park, FS Gazzaniga, DL Kasper… - Experimental & Molecular …, 2023 - nature.com
Our bodies are inhabited by trillions of microorganisms. The host immune system constantly
interacts with the microbiota in barrier organs, including the intestines. Over decades, …

Heterogeneous dysregulation of microRNAs across the autism spectrum

K Abu-Elneel, T Liu, FS Gazzaniga, Y Nishimura… - neurogenetics, 2008 - Springer
microRNAs (miRNAs) are ~21 nt transcripts capable of regulating the expression of many
mRNAs and are abundant in the brain. miRNAs have a role in several complex diseases …

Targeting PD-L2–RGMb overcomes microbiome-related immunotherapy resistance

JS Park, FS Gazzaniga, M Wu, AK Luthens, J Gillis… - Nature, 2023 - nature.com
The gut microbiota is a crucial regulator of anti-tumour immunity during immune checkpoint
inhibitor therapy. Several bacteria that promote an anti-tumour response to immune …

The major reverse transcriptase–incompetent splice variant of the human telomerase protein inhibits telomerase activity but protects from apoptosis

I Listerman, J Sun, FS Gazzaniga, JL Lukas… - Cancer research, 2013 - AACR
Human telomerase reverse transcriptase (hTERT; the catalytic protein subunit of telomerase)
is subjected to numerous alternative splicing events, but the regulation and function of …

Microbial transmission in the social microbiome and host health and disease

…, J Henrich, EA Archie, LB Barreiro, FS Gazzaniga… - Cell, 2024 - cell.com
Although social interactions are known to drive pathogen transmission, the contributions of
socially transmissible host-associated mutualists and commensals to host health and disease …

Gut microbial fatty acid isomerization modulates intraepithelial T cells

…, B Bao, SS Mello, X Sun, W Zheng, FS Gazzaniga… - Nature, 2023 - nature.com
The human gut microbiome constantly converts natural products derived from the host and
diet into numerous bioactive metabolites 1 , 2 – 3 . Dietary fats are essential micronutrients …

Symbionts exploit complex signaling to educate the immune system

…, NA Okan, G Stefanetti, FS Gazzaniga… - Proceedings of the …, 2019 - National Acad Sciences
The mammalian immune system is tolerized to trillions of microbes residing on bodily
surfaces and can discriminate between symbionts and pathogens despite their having related …

An antiapoptotic role for telomerase RNA in human immune cells independent of telomere integrity or telomerase enzymatic activity

FS Gazzaniga, EH Blackburn - Blood, The Journal of the …, 2014 - ashpublications.org
Telomerase is a ribonucleoprotein complex that adds telomeric DNA to the ends of linear
chromosomes. It contains two core canonical components: the essential RNA component, hTR, …

An investigation of the effects of the core protein telomerase reverse transcriptase on Wnt signaling in breast cancer cells

I Listerman, FS Gazzaniga… - Molecular and cellular …, 2014 - Taylor & Francis
Telomerase canonically maintains telomeres, but recent reports have suggested that the core
protein mammalian telomerase reverse transcriptase (TERT) component, together with the …