Accumulating evidence indicates that DNA copy number variation (CNV) is likely to make a
significant contribution to human diversity and also play an important role in disease …

Major depressive disorder (MDD) is a common illness accompanied by considerable
morbidity, mortality, costs, and heightened risk of suicide. We conducted a genome-wide …

… Go search Advanced search … Typically findings that cross this threshold in a primary analysis
have a high rate of replication and go on to show genome-wide evidence of association in …

… early manifestation of symptoms in those who ultimately go on to be diagnosed with bipolar
disorder is … Mignogna KM, Goes FS. Characterizing the longitudinal course of symptoms and …

Background Electroconvulsive therapy (ECT) and subanesthetic intravenous ketamine are
both currently used for treatment-resistant major depression, but the comparative …

Background Lithium is a first-line treatment in bipolar disorder, but individual response is
variable. Previous studies have suggested that lithium response is a heritable trait. However, …

Pancreatic cancer is projected to become the second leading cause of cancer-related death
in the United States by 2020. A familial aggregation of pancreatic cancer has been …

Obsessive-compulsive disorder (OCD) is a psychiatric condition characterized by intrusive
thoughts and urges and repetitive, intentional behaviors that cause significant distress and …

Importance Most previous genome-wide association studies (GWAS) of depression have used
data from individuals of European descent. This limits the understanding of the underlying …

Schizophrenia is a common, clinically heterogeneous disorder associated with lifelong
morbidity and early mortality. Several genetic variants associated with schizophrenia have been …