Increased oxidative stress and cancer biomarkers in the ventral prostate of older rats submitted to maternal malnutrition

LMF Portela, SAA Santos, FB Constantino… - Molecular and cellular …, 2021 - Elsevier
The concept of Developmental Origins of Health and Disease (DOHaD) states that exposure
to malnutrition early in life increase the incidence of non-communicable chronic diseases …

[HTML][HTML] Prediction of non-canonical routes for SARS-CoV-2 infection in human placenta cells

FB Constantino, SS Cury, CR Nogueira… - Frontiers in Molecular …, 2021 - frontiersin.org
The SARS-CoV-2 is the causative agent of the COVID-19 pandemic. The data available
about COVID-19 during pregnancy have demonstrated placental infection; however, the …

Maternal low-protein diet impairs prostate growth in young rat offspring and induces prostate carcinogenesis with aging

…, AC Camargo, FB Constantino… - The Journals of …, 2019 - academic.oup.com
Carcinogenesis is frequently linked to genetic background, however, exposure to environmental
risk factors has gained attention as the etiologic agent for several types of cancer, …

[HTML][HTML] Identification of potential molecular pathways involved in prostate carcinogenesis in offspring exposed to maternal malnutrition

SAA Santos, ACL Camargo, FB Constantino… - Aging (Albany …, 2020 - ncbi.nlm.nih.gov
The developmental origins of health and disease concept links adult diseases with early-life
exposure to inappropriate environmental conditions. Intrauterine and postnatal malnutrition …

Impairment of microvascular angiogenesis is associated with delay in prostatic development in rat offspring of maternal protein malnutrition

…, SAA Santos, ACL Camargo, FB Constantino… - General and …, 2017 - Elsevier
Experimental data demonstrated the negative impact of maternal protein malnutrition (MPM)
on rat prostate development, but the mechanism behind the impairment of prostate growth …

[HTML][HTML] miR-18a-5p is involved in the developmental origin of prostate cancer in maternally malnourished offspring rats: A DOHaD approach

…, LMF Portela, ACL Camargo, FB Constantino… - International Journal of …, 2022 - mdpi.com
The Developmental Origins of Health and Disease (DOHaD) concept correlates early life
exposure to stressor conditions with the increased incidence of non-communicable chronic …

Maternal malnutrition associated with postnatal sugar consumption increases inflammatory response and prostate disorders in rat offspring

…, ACL Camargo, FB Constantino… - Molecular and Cellular …, 2024 - Elsevier
Maternal malnutrition can alter developmental biology, programming health and disease in
offspring. The increase in sugar consumption during the peripubertal period, a worldwide …

Deregulation of ABCG1 early in life contributes to prostate carcinogenesis in maternally malnourished offspring rats

ACL Camargo, FB Constantino, SAA Santos… - Molecular and Cellular …, 2024 - Elsevier
Aims The developmental Origins of Health and Disease (DOHaD) concept has provided the
framework to assess how early life experiences can shape health and disease throughout …

Mucinous metaplasia in Pten conditional knockout mice and mucin family genes as prognostic markers for prostate cancer

NJ Santos, PP Ximenes, FB Constantino, HF Carvalho… - Life sciences, 2022 - Elsevier
Aims This study evaluated the association of mucinous metaplasia (MM) with tumor cell
proliferation, androgen receptor (AR) expression and invasiveness in Pten conditional knockout …

Streptozotocin‐induced maternal hyperglycemia increases the expression of antioxidant enzymes and mast cell number in offspring rat ventral prostate

…, JC Rinaldi, FB Constantino… - The Anatomical …, 2017 - Wiley Online Library
Gestational diabetes mellitus (GDM) has increased in recent years. Although the cellular
and molecular mechanisms involved in GDM‐increased risk factors to offspring remained …